Brugada syndrome (BrS) is a fatal arrhythmia that causes an estimated 4% of all sudden
death in high-incidence areas. SCN5A encodes cardiac sodium channel NaV1. 5 and …

Brugada syndrome (BrS) is associated with ventricular tachycardia originating particularly in
the right ventricle (RV). We explore electrophysiological features predisposing to such …

Background Mutations in the cardiac sodium channel gene SCN5A cause Brugada
syndrome (BrS), an arrhythmic disorder that is a leading cause of sudden death and lacks …

Background—Loss-of-function mutations in Nav1. 5 cause sodium channelopathies,
including Brugada syndrome, dilated cardiomyopathy, and sick sinus syndrome; however …

Variants in SCN10A, which encodes a voltage-gated sodium channel, are associated with
alterations of cardiac conduction parameters and the cardiac rhythm disorder Brugada …

Background Brugada syndrome is a significant cause of sudden cardiac death (SCD), but
the underlying mechanisms remain hypothetical. Objectives This study aimed to elucidate …

Background—Brugada syndrome (BrS) is caused mainly by mutations in the SCN5A gene,
which encodes the α-subunit of the cardiac sodium channel Nav1. 5. However,≈ 20% of …

Brugada syndrome is a rare hereditary arrhythmia disorder characterized by a distinctive
electrocardiogram pattern and an elevated risk of ventricular arrhythmias and sudden …

Abstract Background Brugada syndrome (BrS) is a rare inherited cardiac arrhythmia
associated with a high risk of sudden cardiac death (SCD) due to ventricular fibrillation (VF) …

SCN5A is abundant in heart and has a major role in I Na. Loss-of-function mutation in
SCN5A results in Brugada syndrome (BrS), which causes sudden death in adults. It remains …