Accumulating evidence indicates that disruption of galanin signaling is associated with
neuropsychiatric disease, but the precise functions of this neuropeptide remain largely …

Galanin is a neuropeptide synthesized in many neuronal types including brainstem
norepinephrine-producing cells of the locus coeruleus and the serotonin-producing neurons …

Rationale Galanin and its receptors exert inhibitory neuromodulatory control over brain
monoamines. Rat studies revealed that galanin expression is upregulated by exposure to …

To learn more about molecular alterations in the brain that occur as a consequence of either
the chronic excess or absence of peptide neurotransmitters, we examined the impact of …

There has been increasing interest in the ability of neuropeptides involved in feeding to
modulate circuits important for responses to drugs of abuse. A number of peptides with …

Understanding the role of neuropeptides in mediating emotional behaviors is an important
avenue for discovering novel drug targets for anxiety disorders. A role for galanin in …

The neuropeptide galanin has been implicated in stress-related neuropsychiatric disorders
in humans and rodent models. While pharmacological treatments for these disorders are …

Like a number of neuropeptides, galanin can alter neural activity in brain areas that are
important for both stress-related behaviors and responses to drugs of abuse. Accordingly …

Decades of research confirm that noradrenergic locus coeruleus (LC) neurons are essential
for arousal, attention, motivation, and stress responses. While most studies on LC …

The neuropeptide galanin and its three receptor subtypes (GalR1‐3) are expressed in the
central amygdala (CeA), a brain region involved in stress‐and anxiety‐related behaviors, as …