Galanin receptor-1 knockout mice exhibit spontaneous epilepsy, abnormal EEGs and altered inhibition in the hippocampus

CD McColl, AS Jacoby, J Shine, TP Iismaa… - …, 2006 - Elsevier
Galanin is a widely-distributed neuropeptide that acts as an endogenous anticonvulsant. We
have recently generated a galanin receptor type 1 knockout mouse (Galr1−/−) that develops …

GAL3 receptor KO mice exhibit an anxiety-like phenotype

SM Brunner, A Farzi, F Locker… - Proceedings of the …, 2014 - National Acad Sciences
The neuropeptide galanin (GAL) is widely distributed in the central and peripheral nervous
systems. It is a modulator of various physiological and pathological processes, and it …

The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease

R Lang, AL Gundlach, B Kofler - Pharmacology & therapeutics, 2007 - Elsevier
The galanin peptide family consists of the “parental” galanin, galanin-message-associated
peptide (GMAP) which derives from the same peptide precursor gene product as galanin …

[HTML][HTML] Involvement of neuropeptide galanin receptors 2 and 3 in learning, memory and anxiety in aging mice

F Locker, L Bieler, LMF Nowack, J Leitner, SM Brunner… - Molecules, 2021 - mdpi.com
The neuropeptide galanin (GAL), which is expressed in limbic brain structures, has a strong
impact on the regulation of mood and behavior. GAL exerts its effects via three G protein …

Feeding behaviour in galanin knockout mice supports a role of galanin in fat intake and preference

AC Adams, JC Clapham, D Wynick… - Journal of …, 2008 - Wiley Online Library
It has been widely suggested that saturated fat consumption has fuelled the current obesity
epidemic. Macronutrient choices appear to be important not only as potential factors …

Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity

R Lang, AL Gundlach, FE Holmes, SA Hobson… - Pharmacological …, 2015 - ASPET
Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …

Modulation of hippocampal excitability and seizures by galanin

AM Mazarati, JG Hohmann, A Bacon, H Liu… - Journal of …, 2000 - Soc Neuroscience
Previous studies have shown that the expression of the neuropeptide galanin in the
hippocampus is altered by seizures and that exogenous administration of galanin into the …

Alterations in cerebral cortical galanin concentrations following neurotransmitter-specific subcortical lesions in the rat

SM Gabriel, PJ Knott, V Haroutunian - Journal of Neuroscience, 1995 - Soc Neuroscience
Galanin is associated with multiple projection neurons, and its immunoreactivity in the
cerebral cortex may be derived from diverse sources. We investigated the effects of …

Behavioural characterisation of transgenic mice overexpressing galanin under the PDGF-B promoter

E Kuteeva, T Hökfelt, SO Ögren - Neuropeptides, 2005 - Elsevier
The behavioural phenotype of transgenic mice (3–5-months old) overexpressing galanin
(GalOE mice) under the platelet-derived growth factor B (PDGF-B) promoter was evaluated …

Phenotypic analysis of boldit Galr1 knockout mice reveals a role for GALR1 galanin receptor in modulating seizure activity but not nerve regeneration

AS Jacoby, FE Holmes, YJ Hort, J Shine… - Letters in Peptide …, 2001 - Springer
The GALR1 galanin receptor is expressed at high levels withinthe central nervous system
and is hypothesised to play asignificant role in many of the central actions of galanin …