Galanin receptor-1 knockout mice exhibit spontaneous epilepsy, abnormal EEGs and altered inhibition in the hippocampus
CD McColl, AS Jacoby, J Shine, TP Iismaa… - …, 2006 - Elsevier
Galanin is a widely-distributed neuropeptide that acts as an endogenous anticonvulsant. We
have recently generated a galanin receptor type 1 knockout mouse (Galr1−/−) that develops …
have recently generated a galanin receptor type 1 knockout mouse (Galr1−/−) that develops …
GAL3 receptor KO mice exhibit an anxiety-like phenotype
The neuropeptide galanin (GAL) is widely distributed in the central and peripheral nervous
systems. It is a modulator of various physiological and pathological processes, and it …
systems. It is a modulator of various physiological and pathological processes, and it …
The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease
R Lang, AL Gundlach, B Kofler - Pharmacology & therapeutics, 2007 - Elsevier
The galanin peptide family consists of the “parental” galanin, galanin-message-associated
peptide (GMAP) which derives from the same peptide precursor gene product as galanin …
peptide (GMAP) which derives from the same peptide precursor gene product as galanin …
[HTML][HTML] Involvement of neuropeptide galanin receptors 2 and 3 in learning, memory and anxiety in aging mice
F Locker, L Bieler, LMF Nowack, J Leitner, SM Brunner… - Molecules, 2021 - mdpi.com
The neuropeptide galanin (GAL), which is expressed in limbic brain structures, has a strong
impact on the regulation of mood and behavior. GAL exerts its effects via three G protein …
impact on the regulation of mood and behavior. GAL exerts its effects via three G protein …
Feeding behaviour in galanin knockout mice supports a role of galanin in fat intake and preference
It has been widely suggested that saturated fat consumption has fuelled the current obesity
epidemic. Macronutrient choices appear to be important not only as potential factors …
epidemic. Macronutrient choices appear to be important not only as potential factors …
Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity
R Lang, AL Gundlach, FE Holmes, SA Hobson… - Pharmacological …, 2015 - ASPET
Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …
Modulation of hippocampal excitability and seizures by galanin
AM Mazarati, JG Hohmann, A Bacon, H Liu… - Journal of …, 2000 - Soc Neuroscience
Previous studies have shown that the expression of the neuropeptide galanin in the
hippocampus is altered by seizures and that exogenous administration of galanin into the …
hippocampus is altered by seizures and that exogenous administration of galanin into the …
Alterations in cerebral cortical galanin concentrations following neurotransmitter-specific subcortical lesions in the rat
SM Gabriel, PJ Knott, V Haroutunian - Journal of Neuroscience, 1995 - Soc Neuroscience
Galanin is associated with multiple projection neurons, and its immunoreactivity in the
cerebral cortex may be derived from diverse sources. We investigated the effects of …
cerebral cortex may be derived from diverse sources. We investigated the effects of …
Behavioural characterisation of transgenic mice overexpressing galanin under the PDGF-B promoter
E Kuteeva, T Hökfelt, SO Ögren - Neuropeptides, 2005 - Elsevier
The behavioural phenotype of transgenic mice (3–5-months old) overexpressing galanin
(GalOE mice) under the platelet-derived growth factor B (PDGF-B) promoter was evaluated …
(GalOE mice) under the platelet-derived growth factor B (PDGF-B) promoter was evaluated …
Phenotypic analysis of boldit Galr1 knockout mice reveals a role for GALR1 galanin receptor in modulating seizure activity but not nerve regeneration
AS Jacoby, FE Holmes, YJ Hort, J Shine… - Letters in Peptide …, 2001 - Springer
The GALR1 galanin receptor is expressed at high levels withinthe central nervous system
and is hypothesised to play asignificant role in many of the central actions of galanin …
and is hypothesised to play asignificant role in many of the central actions of galanin …