Galanin receptor subtypes and ligand binding

A Florén, T Land, Ü Langel - Neuropeptides, 2000 - Elsevier
Galanin is a neuropeptide initiating its multiple biological effects by binding to different
subtypes of seven transmembrane spanning galanin receptors, thus transducing the …

Brain galanin system genes interact with life stresses in depression-related phenotypes

G Juhasz, G Hullam, N Eszlari… - Proceedings of the …, 2014 - National Acad Sciences
Galanin is a stress-inducible neuropeptide and cotransmitter in serotonin and
norepinephrine neurons with a possible role in stress-related disorders. Here we report that …

Long-term plastic changes in galanin innervation in the rat basal forebrain

I Hartonian, EJ Mufson, S De Lacalle - Neuroscience, 2002 - Elsevier
Galanin immunoreactive fibers hyperinnervate remaining cholinergic basal forebrain
neurons in Alzheimer's disease, perhaps exacerbating the cholinergic deficit. The purpose …

Differential galanin receptor‐1 and galanin expression by 5‐HT neurons in dorsal raphé nucleus of rat and mouse: evidence for species‐dependent modulation of …

JA Larm, PJ Shen, AL Gundlach - European Journal of …, 2003 - Wiley Online Library
Galanin and galanin receptors are widely expressed by neurons in rat brain that either
synthesize/release and/or are responsive to, classical transmitters such as γ‐aminobutyric …

[HTML][HTML] Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover

KE Smith, C Forray, MW Walker, KA Jones… - Journal of Biological …, 1997 - ASBMB
The neuropeptide galanin is widely distributed throughout the central and peripheral
nervous systems and participates in the regulation of processes such as nociception …

Distribution of galanin receptor 2b neurons and interaction with galanin in the zebrafish central nervous system

E Kim, I Jeong, S Kim, HK Kim, DW Lee, B Kim… - Neuroscience …, 2016 - Elsevier
Galanin is a multifunctional neuropeptide that is implicated in the modulation of
physiological processes, including nociception, cognition, feeding behavior, neuronal …

Neuronal diversity of neuropeptide signaling, including galanin, in the mouse locus coeruleus

M Caramia, RA Romanov… - Proceedings of the …, 2023 - National Acad Sciences
The locus coeruleus (LC) is a small nucleus in the pons from which ascending and
descending projections innervate major parts of the central nervous system. Its major …

Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury

BJ Kerr, WBJ Cafferty, YIK Gupta… - European Journal of …, 2000 - Wiley Online Library
The neuropeptide galanin has been identified as a potential neurotransmitter/
neuromodulator within the central nervous system. In the present study, the role of …

Galanin–25 years with a multitalented neuropeptide: Galanin in Alzheimer's disease: Neuroinhibitory or neuroprotective?

SE Counts, SE Perez, EJ Mufson - Cellular and Molecular Life Sciences, 2008 - Springer
Galanin (GAL) and GAL receptors (GALRs) are overexpressed in degenerating brain
regions associated with cognitive decline in Alzheimer's disease (AD). The functional …

Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice

R Narasimhaiah, HM Kamens, MR Picciotto - Psychopharmacology, 2009 - Springer
Rationale The neuropeptide galanin and its receptors are expressed in brain regions
implicated in the rewarding effects of natural stimuli and drugs of abuse. Galanin has been …