Purpose We evaluated in vitro the role of CO 2-induced oxidative stress on the expression of
proteins involved in cell-cycle regulation of neuroblastoma cells. Methods SH-SY5Y cells …

Background The response of mesothelial cells to surgical trauma and bacterial
contamination is poorly defined. We have recently shown that CO 2 pneumoperitoneum …

The ablative role of minimally invasive surgery (MIS) in neuroblastoma (NB) is still
controversial due to the possible CO₂ pneumoperitoneum side-effects on tumor …

In search for innovative therapeutic agents for children neuroblastoma, the oxygen therapy
could be considered an alternative anti‐tumoral treatment. Given the physiochemical …

Purpose: It has been reported that CO 2 gas, used to establish a pneumoperitoneum during
laparoscopy, affects the behavior of tumor cells. The proto-oncogenes c-myc and HMGB-1 …

Background: Minimally invasive techniques are increasingly applied to children with
malignant tumors. We showed previously that CO 2 used for pneumoperitoneum modulates …

AIM OF STUDY: Reactive oxygen species have been shown to be initiators/promotors of
tumorigenesis. Because evidence supports the role of increased oxidative stress in solid …

Background Reactive oxygen species (ROS) contribute to adult tumorigenesis; however,
their roles in pediatric solid tumors are unknown. Here, we sought to define the steady-state …

RESULTS: The oxidative stress to U251 glioma cells exhibited in a dose-dependent manner
with H2O2 concentrations increasing. The cell viability was considerably decreased and …

The process of cell differentiation goes hand‐in‐hand with metabolic adaptations, which are
needed to provide energy and new metabolites. Carbon monoxide (CO) is an endogenous …