Differential analysis of genome-wide methylation and gene expression in mesenchymal stem cells of patients with fractures and osteoarthritis
A Del Real, FM Pérez-Campo, AF Fernández… - Epigenetics, 2017 - Taylor & Francis
Insufficient activity of the bone-forming osteoblasts leads to low bone mass and predisposes
to fragility fractures. The functional capacity of human mesenchymal stem cells (hMSCs), the …
to fragility fractures. The functional capacity of human mesenchymal stem cells (hMSCs), the …
Genome‐wide DNA methylation analysis during osteogenic differentiation of human bone marrow mesenchymal stem cells
Y Cao, H Yang, L Jin, J Du, Z Fan - Stem cells international, 2018 - Wiley Online Library
Bone marrow mesenchymal stem cells (BMSCs) nowadays are regarded as promising
candidates in cell‐based therapy for the regeneration of damaged bone tissues that are …
candidates in cell‐based therapy for the regeneration of damaged bone tissues that are …
Alterations in DNA methylation profiles in cancellous bone of postmenopausal women with osteoporosis
Y Zhou, L Yang, H Wang, X Chen, W Jiang… - FEBS Open …, 2020 - Wiley Online Library
Osteoporosis is characterized by systemic microarchitecture impairment and bone loss,
which ultimately lead to fragility fractures. This disease is most common in older people …
which ultimately lead to fragility fractures. This disease is most common in older people …
Identification of genes with altered methylation in osteoclast differentiation and its roles in osteoporosis
R Peng, Y Dong, H Kang, Q Guo, M Zhu… - DNA and Cell Biology, 2022 - liebertpub.com
Osteoporosis is one of the most common metabolic skeletal diseases, which affects more
than 200 million people worldwide, especially elderly and postmenopausal women. One of …
than 200 million people worldwide, especially elderly and postmenopausal women. One of …
Genome‐wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis
J Delgado‐Calle, AF Fernández, J Sainz… - Arthritis & …, 2013 - Wiley Online Library
Objective To determine genome‐wide methylation profiles of bone from patients with hip
osteoarthritis (OA) and those with osteoporotic (OP) hip fractures. Methods Trabecular bone …
osteoarthritis (OA) and those with osteoporotic (OP) hip fractures. Methods Trabecular bone …
[HTML][HTML] DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions
Regulation of transcription occurs in a cell type specific manner orchestrated by epigenetic
mechanisms including DNA methylation. Methylation changes may also play a key role in …
mechanisms including DNA methylation. Methylation changes may also play a key role in …
[HTML][HTML] Decoding the regulatory landscape of ageing in musculoskeletal engineered tissues using genome-wide DNA methylation and RNASeq
MJ Peffers, K Goljanek-Whysall, J Collins, Y Fang… - PLoS …, 2016 - journals.plos.org
Mesenchymal stem cells (MSC) are capable of multipotent differentiation into connective
tissues and as such are an attractive source for autologous cell-based regenerative …
tissues and as such are an attractive source for autologous cell-based regenerative …
Global transcriptional profiling using RNA sequencing and DNA methylation patterns in highly enriched mesenchymal cells from young versus elderly women
MM Roforth, JN Farr, K Fujita, LK McCready… - Bone, 2015 - Elsevier
Age-related bone loss in humans is associated with a decrease in bone formation relative to
bone resorption, although the mechanisms for this impairment in bone formation with aging …
bone resorption, although the mechanisms for this impairment in bone formation with aging …
Methylation status of CpG islands in the promoter regions of signature genes during chondrogenesis of human synovium–derived mesenchymal stem cells
Y Ezura, I Sekiya, H Koga, T Muneta… - Arthritis & …, 2009 - Wiley Online Library
Objective Human synovium–derived mesenchymal stem cells (MSCs) can efficiently
differentiate into mature chondrocytes. It has been suggested that DNA methylation is one …
differentiate into mature chondrocytes. It has been suggested that DNA methylation is one …
[HTML][HTML] Osteogenic Differentiation Potential of Mesenchymal Stem Cells Using Single Cell Multiomic Analysis
Mesenchymal stem cells (MSC) are multipotent stem cells that can differentiate into multiple
cell types, including osteoblasts, chondrocytes, and adipocytes. Osteoblast differentiation is …
cell types, including osteoblasts, chondrocytes, and adipocytes. Osteoblast differentiation is …