Mechanisms of action of dendritic cell vaccines for the treatment of cancer

C Zhang, EG Engleman - Drug Discovery Today: Disease Mechanisms, 2006 - Elsevier
Dendritic cells are specialized antigen-presenting cells that play a dual role in induction of
both innate and adaptive immunity as well as T cell tolerance. Dendritic cell based vaccines …

Clinical applications of dendritic cell vaccination in the treatment of cancer

LD Cranmer, KT Trevor, EM Hersh - Cancer Immunology, Immunotherapy, 2004 - Springer
Dendritic cell (DC) immunotherapy has shown significant promise in animal studies as a
potential treatment for cancer. Its application in the clinic depends on the results of human …

The use of dendritic cells in cancer immunotherapy

G Schuler, B Schuler-Thurner, RM Steinman - Current opinion in …, 2003 - Elsevier
A novel approach to vaccination against cancer is to exploit dendritic cells (DCs) as 'nature's
adjuvants' and actively immunize cancer patients with a sample of their own DCs primed …

[PDF][PDF] Dramatic improvement of DC-based immunotherapy against various malignancies

Y Harada, Y Yonemitsu - Front Biosci (Landmark Ed), 2011 - article.imrpress.com
[Frontiers in Bioscience 16, 2233-2242, June 1, 2011] 2233 Dramatic improvement of DC-based
immunotherapy against various malign Page 1 [Frontiers in Bioscience 16, 2233-2242, June 1 …

Dendritic cell vaccines: A review of recent developments and their potential pediatric application

JD Elster, DK Krishnadas, KG Lucas - Human vaccines & …, 2016 - Taylor & Francis
For many cancers the use of conventional chemotherapy has been maximized, and further
intensification of chemotherapy generally results in excess toxicity with little long-term …

Dendritic cell-based immunotherapy for the treatment of hematological malignancies

T Büchler, J Michalek, L Kovarova, R Musilova… - …, 2003 - Taylor & Francis
Dendritic cells (DCs) are professional antigen-presenting cells and are frequently used in
current immunotherapy protocols. The administration of DCs loaded with tumor-associated …

Dendritic cell-based immunotherapy: a basic review and recent advances

J Constantino, C Gomes, A Falcão, BM Neves… - Immunologic …, 2017 - Springer
Dendritic cells (DCs) are considered a very promising arm to activate the immune system in
immunotherapeutic strategies against cancer. DCs are the most powerful antigen-presenting …

Human dendritic cells engineered to express alpha tumor necrosis factor maintain cellular maturation and T-cell stimulation capacity

Z Ye, Z Chen, A Sami, A El-Gayed… - Cancer biotherapy & …, 2006 - liebertpub.com
Dendritic cell (DC) vaccine has been demonstrated to induce antitumor immunity in animal
models. It has been shown that the efficiency of antitumor immunity by DC vaccine is closely …

Genetically engineered dendritic cell-based cancer vaccines

J Bubenik - International journal of oncology, 2001 - spandidos-publications.com
Dendritic cells (DCs) are the most potent professional antigen-presenting cells with exquisite
capacity to interact with T cells and initiate their responses; the antigen-presenting …

Clinical considerations in developing dendritic cell vaccine based immunotherapy protocols in cancer

V Murthy, A Moiyadi, R Sawant… - Current molecular …, 2009 - ingentaconnect.com
Since the first reported clinical trial of Dendritic Cell Vaccine (DCV) in cancer in the mid
nineties, few hundred clinical trials have been initiated and it was projected that over 3000 …