Background Clear cell renal cell carcinoma (ccRCC), the most aggressive renal cancer, is
characterized by early lymph node metastases and bad prognosis. Most therapies targeting …

Simple Summary Renal cell carcinoma is particularly characterized by its high
vascularization and dense immune cells infiltration. The angiogenesis blockade in …

Simple Summary To summarise the data on the combination of antiangiogenic and immune
checkpoints in the treatment of clear-cell renal-cell carcinoma. In this review, we detail the …

Simple Summary In the last 15 years, a deep improvement in the knowledge regarding the
biological mechanisms responsible for neoplastic cell development and progression has led …

In the last few years, the standard of care for metastatic clear cell renal cell carcinoma
(mccRCC) has changed dramatically with the emergence of the immune checkpoint …

Simple Summary To summarize the main discoveries made over the past few years to treat
metastatic clear cell renal cell carcinoma, including different generations of anti-VEGF TKIs …

Simple Summary Kidney cancer has many forms, which fall under the overall term, renal cell
carcinoma. Clear cell renal cell carcinoma is by far the most common type, and all other …

Abstract Background Immune checkpoint inhibitors (ICIs) are being increasingly utilised in
the front-line (1L) setting of metastatic clear-cell renal cell carcinoma (mccRCC). Limited …

Approximately 400,000 patients are diagnosed with kidney cancer annually worldwide,
leading to approximately 170,000 deaths. Renal cell carcinoma (RCC) accounts for more …

The prognosis for advanced clear cell renal cell carcinoma (ccRCC) is not satisfactory, even
though its treatment has evolved rapidly over the past 20 years. Systemic ccRCC treatment …