Pain-Related Behavior and Potential Confounds in the Study of Laboratory Animals Page 1
Pain-Related Behavior and Potential Confounds in the Study of Laboratory Animals Andrea …

We report the development and characterization of a novel, injury-free rat model in which
nociceptive sensitization after red light is observed in multiple body areas reminiscent of …

To characterize nocifensive behavior, a laser beam was applied to the hind footpad of
nonanesthetized and unrestrained rats and the reaction pattern was analyzed. Fifty-four rats …

Defining pain, distress and suffering Defining the essentially human concepts of pain,
distress and suffering is inherently dif-ficult especially when dealing with such ex-periences …

Nociceptive reflexes are predominant in traditional “pain” tests using rodents. However, pain
is not a nociceptive reflex, but an unpleasant personal experience associated with a …

Experienced basic (rodent) pain researchers appreciate the influence of subject behavior
during nociceptive testing, but such factors are not commonly reported and have not been …

Pain research has always been hampered by the subjective nature of the phenomenon. In
addition to the complexities of the independent variables being applied, pain researchers …

Pain is mediated by functionally distinctive components. It may involve acute high threshold
afferent stimuli (thermal, mechanical or chemically damaged tissue), protracted afferent input …

In the preclinical study of pain, two commonly used pain models are the L5 spinal nerve
ligation (SNL) and the injection of carrageenan. Using a modified place escape/avoidance …

Exposure of rats for 2 min to a new environment (a 50× 25× 25-cm box) induced a mild
analgesia measured by the tail-flick method. Additional stressful stimuli (0.5 mA, 1.5-s …