Objective: Loss-of-function mutations in the progranulin gene (PGRN) were identified in
frontotemporal lobar degeneration (FTLD) with ubiquitin-immunoreactive neuronal …

Two genetically distinct types of frontotemporal dementia (FTD) are linked to chromosome
17q21. FTD with parkinsonism (FTDP-17) results from mutations in the gene encoding …

Progranulin (PGRN) is a multifunctional protein that is widely expressed throughout the
brain, where it has been shown to act as a critical regulator of CNS inflammation and also …

Progranulin (PGRN) is an estrogen-inducible growth factor thought to affect multiple
processes in the CNS, including brain sexual differentiation, adult neurogenesis in the …

Loss-of-function mutations in GRN cause frontotemporal dementia (FTD) with transactive
response DNA-binding protein of 43 kD (TDP-43)–positive inclusions and neuronal ceroid …

Frontotemporal dementia (FTD) is a clinical term encompassing dementia characterized by
the presence of two major phenotypes: 1) behavioral and personality disorder, and 2) …

Abstract Ubiquitin‐positive, tau‐negative, frontotemporal dementia (FTD) is caused by null
mutations in progranulin (PGRN; HUGO gene symbol GRN), suggesting a haploinsufficiency …

Background Progranulin (PGRN) is a secreted growth factor important for neuronal survival
and may do so, in part, by regulating lysosome homeostasis. Mutations in the PGRN gene …

Background Progranulin loss-of-function mutations are linked to frontotemporal lobar
degeneration with TDP-43 positive inclusions (FTLD-TDP-Pgrn). Progranulin (PGRN) is an …

Haploinsufficiency of the progranulin (PGRN) gene (GRN) causes familial frontotemporal
lobar degeneration (FTLD) and modulates an innate immune response in humans and in …