Abstract Treatment options for managing traumatic brain injury remain limited. Therapies
that limit the development of secondary brain injury—the delayed injury that can occur days …

Inflammation is an important part of the pathophysiology of traumatic brain injury. Although
the central nervous system differs from the other organs because of the almost complete …

Highlights•TBI is the main cause of death and disability in children and young
adults.•Secondary brain injury may occur for month and years after injury.•Cognitive decline …

TBI has been one of the top causes of death and morbidity worldwide, yet despite enormous
efforts to discover neuroprotective therapeutics for this serious disease, no beneficial …

Traumatic brain injury (TBI) remains one of the leading causes of mortality and morbidity
worldwide, yet despite extensive efforts to develop neuroprotective therapies for this …

There is an increasing evidence that inflammation contributes to clinical and functional
outcomes in traumatic brain injury (TBI). Many successful target-engaging, lesion-reducing …

Traumatic brain injury (TBI) affects an ever-growing population of all ages with long-term
consequences on health and cognition. Many of the issues that TBI patients face are thought …

The'silent epidemic'of traumatic brain injury (TBI) has been placed in the spotlight as a result
of clinical investigations and popular press coverage of athletes and veterans with single or …

The pathophysiology of degenerative, infectious, inflammatory and traumatic diseases of the
central nervous system includes a significant immune component. As to the latter, damage to …

Neuroinflammation is initiated as a result of traumatic brain injury and can exacerbate
evolving tissue pathology. Immune cells respond to acute signals from damaged cells …