In vitro assays: friends or foes of cell-penetrating peptides
J Liu, S Afshar - International Journal of Molecular Sciences, 2020 - mdpi.com
The cell membrane is a complex and highly regulated system that is composed of lipid
bilayer and proteins. One of the main functions of the cell membrane is the regulation of cell …
bilayer and proteins. One of the main functions of the cell membrane is the regulation of cell …
Studying the uptake of cell-penetrating peptides
T Holm, H Johansson, P Lundberg, M Pooga… - Nature protocols, 2006 - nature.com
More than a decade ago, it was discovered that cationic peptides could traverse the cellular
plasma membrane without specific transporter proteins or membrane damage …
plasma membrane without specific transporter proteins or membrane damage …
Break on through to the other side—biophysics and cell biology shed light on cell‐penetrating peptides
R Fischer, M Fotin‐Mleczek, H Hufnagel… - …, 2005 - Wiley Online Library
Cell‐penetrating peptides (CPPs) have become widely used vectors for the cellular import of
molecules in basic and applied biomedical research. Despite the broad acceptance of these …
molecules in basic and applied biomedical research. Despite the broad acceptance of these …
Challenge to overcome current limitations of cell-penetrating peptides
The penetration of biological membranes is a prime obstacle for the delivery of
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …
Cell-penetrating peptides: A comparative study on lipid affinity and cargo delivery properties
P Ruzza, B Biondi, A Marchiani, N Antolini, A Calderan - Pharmaceuticals, 2010 - mdpi.com
A growing number of natural and/or synthetic peptides with cell membrane penetrating
capability have been identified and described in the past years. These molecules have been …
capability have been identified and described in the past years. These molecules have been …
Effects of Tryptophan Content and Backbone Spacing on Uptake Efficiency of Cell-Penetrating Peptides
HA Rydberg, M Matson, HL Åmand, EK Esbjörner… - Biophysical …, 2012 - cell.com
Cell-penetrating peptides (CPPs) have recently gained considerable interest due to their
ability to cross cellular membranes and deliver macromolecular cargo. It is of great …
ability to cross cellular membranes and deliver macromolecular cargo. It is of great …
On the importance of electrostatic interactions between cell penetrating peptides and membranes: a pathway toward tumor cell selectivity?
ML Jobin, ID Alves - Biochimie, 2014 - Elsevier
Cell-penetrating peptides (CPPs) are small molecules of major interest due to their ability to
efficiently transport cargos across cell membranes in a receptor-and energy-independent …
efficiently transport cargos across cell membranes in a receptor-and energy-independent …
[PDF][PDF] Translocation of cell-penetrating peptides across biological membranes and interactions with plasma membrane constituents
J Pae - 2016 - core.ac.uk
Introduction of a vast number of biomolecules with high therapeutic potential into
experimental medical and clinical practice is hampered by the poor plasma membrane …
experimental medical and clinical practice is hampered by the poor plasma membrane …
Applications and challenges for use of cell-penetrating peptides as delivery vectors for peptide and protein cargos
The hydrophilic nature of peptides and proteins renders them impermeable to cell
membranes. Thus, in order to successfully deliver peptide and protein-based therapeutics …
membranes. Thus, in order to successfully deliver peptide and protein-based therapeutics …
[HTML][HTML] Assessing the uptake kinetics and internalization mechanisms of cell-penetrating peptides using a quenched fluorescence assay
I Mäger, E Eiríksdóttir, K Langel, SEL Andaloussi… - … et Biophysica Acta (BBA …, 2010 - Elsevier
Cell-penetrating peptides (CPPs) have shown great potency for cargo delivery both in vitro
and in vivo. Different biologically relevant molecules need to be delivered into appropriate …
and in vivo. Different biologically relevant molecules need to be delivered into appropriate …