When almost 60% of the world's population is predicted to be overweight by 2030 [1], dosing
regimens that are developed and tested in non-obese patients will be inappropriate for the …

Introduction Obesity is an increasingly common comorbidity in critically ill patients. Whether
obesity alters sepsis outcome, susceptibility, treatment, and response is not completely …

To the Editor:“Obesity paradox,” the phenomenon that obesity increases the risk of obesity-
related diseases but paradoxically is associated with a survival benefit, has been observed …

Introduction Data are sparse as to whether obesity influences the risk of death in critically ill
patients with septic shock. We sought to examine the possible impact of obesity, as …

As the prevalence of obesity continues to rise significantly worldwide, an increasing number
of overweight patients are expected to present to hospital with various pathological …

Abstract Introduction Two thirds of United States adults are overweight or obese, which puts
them at higher risk of developing chronic diseases and of death compared with normal …

Background This review has been developed following a panel discussion with an
international group of experts in the care of patients with obesity in the critical care setting …

Background At least 25% of adults admitted to intensive care units (ICU) in the United States
have an overweight, obese or morbidly obese body mass index (BMI). The effect of BMI on …

In order to eradicate an infecting organism, it is necessary to achieve or maintain
concentrations of an antibiotic in vivo that exceed the minimum inhibitory concentration …

Background Limited data are available assessing vancomycin concentrations in obese
critically ill patients. Currently, there are no studies evaluating dosing requirements in this …