Nanoparticles exhibiting virus-mimic surface topology for enhanced oral delivery
Z Sang, L Xu, R Ding, M Wang, X Yang, X Li… - Nature …, 2023 - nature.com
The oral delivery of nano-drug delivery systems (Nano-DDS) remains a challenge. Taking
inspirations from viruses, here we construct core–shell mesoporous silica nanoparticles …
inspirations from viruses, here we construct core–shell mesoporous silica nanoparticles …
Biomimetic engineered nanocarriers inspired by viruses for oral-drug delivery
JY Zhang, XX Liu, JY Lin, XY Bao, JQ Peng… - International Journal of …, 2022 - Elsevier
Oral administration is the most preferred and simplest route, but it is highly challenging due
to the numerous barriers in the gastrointestinal tract. To overcome these barriers …
to the numerous barriers in the gastrointestinal tract. To overcome these barriers …
Biomimetic viruslike and charge reversible nanoparticles to sequentially overcome mucus and epithelial barriers for oral insulin delivery
J Wu, Y Zheng, M Liu, W Shan, Z Zhang… - ACS applied materials …, 2018 - ACS Publications
Nanoparticles (NPs) for oral delivery of peptide/protein drugs are largely limited due to the
coexistence of intestinal mucus and epithelial barriers. Sequentially overcoming these two …
coexistence of intestinal mucus and epithelial barriers. Sequentially overcoming these two …
Sub‐50 nm nanoparticles with biomimetic surfaces to sequentially overcome the mucosal diffusion barrier and the epithelial absorption barrier
X Zhu, J Wu, W Shan, Z Zhou, M Liu… - Advanced Functional …, 2016 - Wiley Online Library
Although nanoparticles (NPs) have been used for many drug delivery applications, oral
absorption of NPs has remained a big challenge. NPs for oral delivery of biotherapeutics …
absorption of NPs has remained a big challenge. NPs for oral delivery of biotherapeutics …
Chiral nanosilica drug delivery systems stereoselectively interacted with the intestinal mucosa to improve the oral adsorption of insoluble drugs
X Chen, Y Cheng, Q Pan, L Wu, X Hao, Z Bao, X Li… - ACS …, 2023 - ACS Publications
Chiral nanoparticles (NPs) with nanoscale rough surfaces have enormous application
prospects in drug delivery. However, the stereoselective interactions between the chiral NPs …
prospects in drug delivery. However, the stereoselective interactions between the chiral NPs …
Tobacco mosaic virus-functionalized mesoporous silica nanoparticles, a wool-ball-like nanostructure for drug delivery
L Marín-Caba, PL Chariou, C Pesquera… - Langmuir, 2018 - ACS Publications
The design of versatile tools to improve cell targeting and drug delivery in medicine has
become increasingly pertinent to nanobiotechnology. Biological and inorganic nanocarrier …
become increasingly pertinent to nanobiotechnology. Biological and inorganic nanocarrier …
Virus spike and membrane-lytic mimicking nanoparticles for high cell binding and superior endosomal escape
Virus-inspired mimics for gene therapy have attracted increasing attention because viral
vectors show robust efficacy owing to the highly infectious nature and efficient endosomal …
vectors show robust efficacy owing to the highly infectious nature and efficient endosomal …
Carrier-free nanodrug-based virus-surface-mimicking nanosystems for efficient drug/gene co-delivery
Nature-inspired nanoparticles, from pathogens to mammalian cells, have attracted
increasing attention, for their specific functions and unparalled features that are often …
increasing attention, for their specific functions and unparalled features that are often …
Net-Neutral Nanoparticles-Extruded Microcapsules for Oral Delivery of Insulin
X Lu, J Li, M Xue, M Wang, R Guo… - … Applied Materials & …, 2023 - ACS Publications
Oral delivery of insulin could widely improve the quality of life of diabetic patients but still
requires further exploration. Commonly utilized oral delivery vehicles hardly penetrate the …
requires further exploration. Commonly utilized oral delivery vehicles hardly penetrate the …
Virus-mimicking mesoporous silica nanoparticles with an electrically neutral and hydrophilic surface to improve the oral absorption of insulin by breaking through dual …
Y Zhang, M Xiong, X Ni, J Wang, H Rong… - … Applied Materials & …, 2021 - ACS Publications
Protein and peptide drugs orally suffer from extremely low bioavailability principally for the
complicated gastrointestinal environment along with the difficulty of passing through the …
complicated gastrointestinal environment along with the difficulty of passing through the …