Oral administration of protein drugs is greatly impeded by the lack of drug carriers that can
efficiently overcome the absorption barriers of mucosa tissue, which consists of not only …

Nanoparticles (NPs) have demonstrated great potential for the oral delivery of protein drugs
that have very limited oral bioavailability. Orally administered NPs could be absorbed by the …

Trimethyl chitosan-cysteine conjugate (TMC-Cys) was synthesized in an attempt to combine
the mucoadhesion and the permeation enhancing effects of TMC and thiolated polymers …

Mucoadhesive and mucopenetrating nanoparticles are commonly designed to improve
mucosal drug delivery efficiency. Herein, in order to better understand the contribution of …

Oral administration of insulin remains a challenge due to its poor enzymatic stability and
inefficient permeation across epithelium. We herein developed a novel self-assembled …

Although nanoparticles (NPs) have been used for many drug delivery applications, oral
absorption of NPs has remained a big challenge. NPs for oral delivery of biotherapeutics …

The aim of this work was to investigate the role of mucoadhesion in the insulin uptake of
nanocomplexes (NC) based of trimethyl chitosan (TMC) and poly (ethylene glycol)(PEG) …

Despite advances in drug-delivery technologies, successful oral administration of protein
drugs remains an elusive challenge. When protein drugs are administered orally, they can …

Oral administration is a highly attractive approach for the delivery of protein drugs. However,
oral protein therapeutics typically exhibit extremely poor bioavailability due to the harsh …

Chitosan nanoparticles (CS NPs) have been commonly regarded as potential carriers for the
mucosal delivery of therapeutic peptides because of their biocompatibility, bioadhesion and …