Oral administration is a highly attractive approach for the delivery of protein drugs. However,
oral protein therapeutics typically exhibit extremely poor bioavailability due to the harsh …

Chitosan nanoparticles (CS NPs) have been commonly regarded as potential carriers for the
mucosal delivery of therapeutic peptides because of their biocompatibility, bioadhesion and …

Overcoming epithelial barriers to enhance drug absorption is a major challenge for
nanoparticle (NP)-based mucosal delivery systems. With adequate physicochemical …

The aim of this paper was to evaluate the penetration enhancement properties of
nanoparticles (NP) based on N-trimethyl chitosan (TMC 35% quaternization degree) loaded …

Although several strategies have been applied for oral insulin delivery to improve insulin
bioavailability, little success has been achieved. To overcome multiple barriers to oral …

In this study, insulin-loaded nanoparticles (NPs) were prepared via self-gelation method
using chitosan and aqueous soluble snail mucin as natural polymers. Herein, mucins were …

Nanotechnology based drug delivery systems are anticipated to overcome the persistent
challenges in oral protein and peptide administration, and lead to the development of long …

The objective of this study was to design intestinal mucus-penetrating core-shell
nanocomplex by functionally mimicking the surface of virus, which can be used as the carrier …

Nanoparticles (NPs) for oral delivery of peptide/protein drugs are largely limited due to the
coexistence of intestinal mucus and epithelial barriers. Sequentially overcoming these two …

Oral protein drug delivery using nano-based systems remains challenging, as contradictory
surface properties are required for efficient navigation through the intestinal mucus and …