Nanoparticles have opened a new perspective for oral drug delivery. However, nanoparticle
transport is strongly hindered by mucus and epithelial barriers before they can enter the …

Oral delivery of proteins such as insulin has been a long‐lasting challenge owing to
gastrointestinal degradation and poor permeability of therapeutic macromolecules across …

Diabetes mellitus is a highly prevalent metabolic and chronic disease affecting millions of
people in the world. The most common route of insulin therapy is the subcutaneous injection …

Background Oral administration of insulin (INS) could be absorbed into systemic circulation
only if the carrier protected it from the hostile gastrointestinal conditions. However, traditional …

In this study, the effects of alginate modification on absorption properties of FITC-BSA
loaded TMC nanoparticles were investigated on an in vitro model of GI epithelium (Caco-2 …

The intestinal epithelial and mucus barriers on the gastrointestinal tract limit the
bioavailability of oral protein or peptide drugs. Therefore, efficient mucus permeability and …

Mucus is a dynamic barrier which covers and protects the underlying mucosal epithelial
membrane against bacteria and foreign particles. This protection mechanism extends to …

Poor permeation across intestinal mucous barriers often limits the oral delivery of
prospective therapeutic proteins and peptides (TPPs). In order to address this issue, cell …

In the study, chitosan (CS) was conjugated with trimethyl groups for the synthesis of N-
trimethyl chitosan (TMC) polymers with different degrees of quaternization. Nanoparticles …

A variety of approaches have been studied in the past to overcome the problems
encountered with the oral delivery of insulin, but with little success. In this study, self …