There are many ongoing investigations to improve the oral bioavailability of peptide and
protein formulations. Bioadhesive polysaccharide chitosan nanoparticles (CS-NPs) would …

Nanoparticulate drug delivery systems offer remarkable opportunities for clinical treatment.
However, there are several challenges when they are employed to deliver multiple …

Mucoadhesive nanoparticles (NPs) could be an exciting prospect for trans-nasal insulin
delivery as they have higher surface area to cover highly vascularised nasal absorptive area …

Particle diffusion through the intestinal mucosal barrier is restricted by the viscoelastic and
adhesive properties of the mucus gel layer, preventing their penetration to the underlying …

As 95% of all prescriptions are for orally administered drugs, the issue of oral absorption is
central to the development of pharmaceuticals. Oral absorption is limited by a high …

To improve the efficiency of insulin via oral administration, pH-sensitive carboxylated
chitosan grafted poly (methyl methacrylate) nanoparticles (CCGN) were prepared. CCGN …

Abstract To improve Biopharmaceutics Classification System class IV drug bioavailability,
mucus and underlying intestinal epithelial barriers must be overcome. Hydrophilic …

This study was aimed at utilizing polysaccharides for the development of effective hydrogel
microparticles for oral insulin delivery that has a controlled, and sustained release to …

The present study investigates the potential of layer by layer coated calcium phosphate
nanoparticles–for oral delivery of insulin where Vitamin B12 grafted chitosan and sodium …

During the last decades, advanced oral delivery systems to enhance the intestinal
absorption of widely applicable proteins and peptides, particularly insulin, have been …