The role of amiodarone in contemporary management of complex cardiac arrhythmias

N Mujović, D Dobrev, M Marinković, V Russo… - Pharmacological …, 2020 - Elsevier
Amiodarone is an iodinated benzofuran derivative, a highly lipophilic drug with
unpredictable pharmacokinetics. Although originally classified as a class III agent due to its …

Amiodarone: the expanding antiarrhythmic role and how to follow a patient on chronic therapy

BN Singh - Clinical cardiology, 1997 - Wiley Online Library
Amiodarone was introduced as an antiarrhythmic compound in the early 1970s and was
approved in the US for the treatment of refractory ventricular arrhythmias in late 1984. Since …

Amiodarone: an overview of its pharmacological properties, and review of its therapeutic use in cardiac arrhythmias

J Gill, RC Heel, A Fitton - Drugs, 1992 - Springer
Synopsis Amiodarone, originally developed over 20 years ago, is a potent antiarrhythmic
drug with the actions of all antiarrhythmic drug classes. It has been successfully used in the …

Amiodarone: pharmacology and antiarrhythmic and adverse effects

GV Naccarelli, RL Rinkenberger… - … : The Journal of …, 1985 - Wiley Online Library
Amiodarone is a benzofuran derivative that has been effective for the treatment of both
supraventricular and ventricular tachyarrhythmias. It has a large volume of distribution …

Antiarrhythmic actions of amiodarone: a profile of a paradoxical agent

BN Singh - The American journal of cardiology, 1996 - Elsevier
Amiodarone, a complex compound with variegated electropharmacologic and
pharmacokinetic properties and an equally complex side-effect profile, continues to have a …

Amiodarone: clinical trials

GV Naccarelli, DL Wolbrette, HM Patel… - Current Opinion in …, 2000 - journals.lww.com
Amiodarone is an antiarrhythmic agent commonly used in the treatment of supraventricular
and ventricular tachyarrhythmias. This article reviews the results and clinical implications of …

Expanding indications for the use of class III agents in patients at high risk for sudden death

BN Singh - Journal of Cardiovascular Electrophysiology, 1995 - Wiley Online Library
Expanding Indications of Class III Agents. The evidence that antiarrhythmic compounds that
act by slowing conduction velocity increase mortality in patients with cardiac disease is now …

Amiodarone as paradigm for developing new drugs for atrial fibrillation

BN Singh - Journal of Cardiovascular Pharmacology, 2008 - journals.lww.com
Introduced as an anti-anginal compound in 1962, amiodarone emerged in the 1970s as a
uniquely effective antiarrhythmic and antifibrillatory drug with a multiplicity of properties, the …

Amiodarone for the treatment and prevention of ventricular fibrillation and ventricular tachycardia

H Van Herendael, P Dorian - Vascular health and risk …, 2010 - Taylor & Francis
Amiodarone has emerged as the leading antiarrhythmic therapy for termination and
prevention of ventricular arrhythmia in different clinical settings because of its proven …

Amiodarone: what have we learned from clinical trials?

GV Naccarelli, DL Wolbrette, JT Dell'Orfano… - Clinical …, 2000 - Wiley Online Library
Amiodarone is an antiarrhythmic agent commonly used in the treatment of supraventricular
and ventricular tachyarrhythmias. This paper reviews clinical trials in which amiodarone was …