Background/Objective: To determine the impact of vascular burden on rates of decline in
episodic memory and executive function. We hypothesize that greater vascular burden will …

Objective To determine whether vascular and neurodegenerative factors influence cognition
before clinically relevant Alzheimer disease pathology, we analyzed MRI measures and …

Cardiovascular disease (CVD) is associated with a higher risk of developing dementia.
Studies have found that vascular risk factors are associated with greater amyloid-β (Aβ) and …

Objective: To investigate the vascular contribution to longitudinal changes in Alzheimer
disease (AD) biomarkers. Methods: The Alzheimer's Disease Neuroimaging Initiative is a …

Importance Identifying asymptomatic individuals at high risk of impending cognitive decline
because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk …

It remains unclear to what extent cerebrovascular burden relates to amyloid beta (Aβ)
deposition, neurodegeneration, and cognitive dysfunction in mixed disease populations with …

Our primary objective was to investigate a biomarker driven model for the interrelationships
between vascular disease pathology, amyloid pathology, and longitudinal cognitive decline …

Importance β-Amyloid (Aβ) deposition and vascular brain injury (VBI) frequently co-occur
and are both associated with cognitive decline in aging. Determining whether a direct …

Introduction Little is known about how antecedent vascular risk factor (VRF) profiles impact
late‐life brain health. Methods We examined baseline VRFs, and cognitive testing and …

Objective To evaluate the association between brain amyloid β (Aβ) and cerebral small
vessel disease (CSVD) markers, as well as their joint effect on cognition, in a memory clinic …