Background Cystic fibrosis (CF) is an inherited disorder causing impaired mucociliary
clearance within the respiratory tract, and is associated with bronchiectasis, chronic …

Abnormal mucociliary clearance (MCC) is one of the central hypotheses for the development
of lung disease in patients with cystic fibrosis (CF). However, attempts to demonstrate this …

Cystic fibrosis (CF) lung disease is characterised by defective clearance of airway secretions
that are hyperconcentrated, viscous, and serve as the nidus of chronic polymicrobial …

In cystic fibrosis (CF) the mucociliary clearance mechanism is impaired and airway
clearance techniques aim to compensate for this by promoting secretion clearance. A …

Impaired mucociliary clearance is a hallmark of cystic fibrosis (CF). Early morphological
changes first appear in the small airways. Lung clearance was investigated in 11 young CF …

Current concepts of cystic fibrosis (CF) pathophysiology link ion transport abnormalities to
reduced airway surface liquid (ASL) hydration and impaired mucus clearance. It is likely that …

Extract A hallmark of cystic fibrosis (CF) is build-up of thick tenacious mucus, leading to
progressive cycles of infection and inflammation. Airway clearance techniques (ACTs) are a …

Cystic fibrosis (CF) is a genetic disease characterized by an accumulation of thick layers of
mucus, leading to airway obstruction and air trapping. Poorly cleared mucus leads to …

The airways of the patient with cystic fibrosis (CF) are chronically infected. There is excess
mucus within the airways and, because of the chronic infection, the mucus also contains …

Study objective It has been suggested that the defective cyclic AMP-dependent Cl–secretion
and the increased Na+ absorption from airway epithelia in cystic fibrosis (CF) may lead to …