Looking at the Pathogenesis of the Rabies Lyssavirus Strain Pasteur Vaccins through a Prism of the Disorder-Based Bioinformatics

S Dhulipala, VN Uversky - Biomolecules, 2022 - mdpi.com
Rabies is a neurological disease that causes between 40,000 and 70,000 deaths every
year. Once a rabies patient has become symptomatic, there is no effective treatment for the …

Intrinsic Disorder in the Host Proteins Entrapped in Rabies Virus Particles

HN Ashraf, VN Uversky - Viruses, 2024 - mdpi.com
A proteomics analysis of purified rabies virus (RABV) revealed 47 entrapped host proteins
within the viral particles. Out of these, 11 proteins were highly disordered. Our study was …

Quantitative proteomics leads to identify dog brain proteins involved in rabies virus infection: implication in understanding viral pathophysiology

S Behera, RR Pharande, RR Reddy, SB Majee… - Journal of Proteins and …, 2020 - Springer
Rabies is a neglected tropical disease caused by the rabies virus (RABV) and it is mostly
transmitted to humans by dogs. However, knowledge about host factors and their role in …

[PDF][PDF] Large protein as a potential target for use in rabies diagnostics

ISS Katz, MH Dias, IF Lima, LB Chaves, OG Ribeiro… - Acta Virol, 2017 - academia.edu
Rabies is a zoonotic viral disease that remains a serious threat to public health worldwide.
The rabies lyssavirus (RABV) genome encodes five structural proteins, multifunctional and …

Japanese encephalitis virus–exploring the dark proteome and disorder–function paradigm

T Bhardwaj, KU Saumya, P Kumar, N Sharma… - The FEBS …, 2020 - Wiley Online Library
Japanese encephalitis virus (JEV) is one of the major causes of viral encephalitis all around
the globe. Approximately 3 billion people in endemic areas are at risk of Japanese …

Structural disorder in the proteome and interactome of Alkhurma virus (ALKV)

EM Redwan, AA AlJaddawi, VN Uversky - Cellular and Molecular Life …, 2019 - Springer
Infection by the Alkhurma virus (ALKV) leading to the Alkhurma hemorrhagic fever is a
common thread in Saudi Arabia, with no efficient treatment or prevention available as of yet …

Exploring the conformational landscape of the rabies virus glycoprotein using HDX-MS

SR Shoemaker, TX Li, W Wu, JE Pak, S Marqusee - Biophysical Journal, 2023 - cell.com
Rabies virus, a member of the lyssavirus family, causes on the order of 60,000 deaths per
year, disproportionately affecting historically exploited regions of the world. While …

Comprehensive intrinsic disorder analysis of 6108 viral proteomes: from the extent of intrinsic disorder penetrance to functional annotation of disordered viral proteins

N Kumar, R Kaushik, C Tennakoon… - Journal of Proteome …, 2021 - ACS Publications
Much of our understanding of proteins and proteomes comes from the traditional protein
structure–function paradigm. However, in the last 2 decades, both computational and …

Insights into the evolutionary forces that shape the codon usage in the viral genome segments encoding intrinsically disordered protein regions

N Kumar, R Kaushik, C Tennakoon… - Briefings in …, 2021 - academic.oup.com
Intrinsically disordered regions/proteins (IDRs) are abundant across all the domains of life,
where they perform important regulatory roles and supplement the biological functions of …

Systems biomedicine of rabies delineates the affected signaling pathways

S Azimzadeh Jamalkandi, SH Mozhgani… - Frontiers in …, 2016 - frontiersin.org
The prototypical neurotropic virus, rabies, is a member of the Rhabdoviridae family that
causes lethal encephalomyelitis. Although there have been a plethora of studies …