Microbial population polymorphisms are commonly observed in natural environments,
including long-term infected hosts. However, the underlying processes promoting and …

Pulmonary infections caused by Pseudomonas aeruginosa are a recalcitrant problem in
cystic fibrosis (CF) patients. While the clinical implications and long-term evolutionary …

Chronic infection of the cystic fibrosis (CF) airway by the opportunistic pathogen
Pseudomonas aeruginosa is the leading cause of morbidity and mortality for adult CF …

The comparative genomics of the transition of the opportunistic pathogen Pseudomonas
aeruginosa from a free-living environmental strain to one that causes chronic infection in the …

Pseudomonas aeruginosa chronic infections of cystic fibrosis (CF) airways are a paradigm
for within-host evolution with abundant evidence for rapid evolutionary adaptation and …

ABSTRACT The Gram-negative bacterium Pseudomonas aeruginosa is a common cause of
chronic airway infections in individuals with the heritable disease cystic fibrosis (CF). After …

Pseudomonas aeruginosa notoriously adapts to the airways of people with cystic fibrosis
(CF), yet how infection-site biogeography and associated evolutionary processes vary as …

Pseudomonas aeruginosa populations undergo a characteristic evolutionary adaptation
during chronic infection of the cystic fibrosis (CF) lung, including reduced production of …

Laboratory evolution experiments have led to important findings relating organism
adaptation and genomic evolution. However, continuous monitoring of long-term evolution …

Abstract The Cystic Fibrosis (CF) lung harbors a complex, polymicrobial ecosystem, in which
Pseudomonas aeruginosa is capable of sustaining chronic infections, which are highly …