Environmental heterogeneity drives within-host diversification and evolution of Pseudomonas aeruginosa
T Markussen, RL Marvig, M Gómez-Lozano, K Aanæs… - MBio, 2014 - Am Soc Microbiol
Microbial population polymorphisms are commonly observed in natural environments,
including long-term infected hosts. However, the underlying processes promoting and …
including long-term infected hosts. However, the underlying processes promoting and …
Selective sweeps and parallel pathoadaptation drive Pseudomonas aeruginosa evolution in the cystic fibrosis lung
J Diaz Caballero, ST Clark, B Coburn, Y Zhang… - MBio, 2015 - Am Soc Microbiol
Pulmonary infections caused by Pseudomonas aeruginosa are a recalcitrant problem in
cystic fibrosis (CF) patients. While the clinical implications and long-term evolutionary …
cystic fibrosis (CF) patients. While the clinical implications and long-term evolutionary …
Rapid diversification of Pseudomonas aeruginosa in cystic fibrosis lung-like conditions
Chronic infection of the cystic fibrosis (CF) airway by the opportunistic pathogen
Pseudomonas aeruginosa is the leading cause of morbidity and mortality for adult CF …
Pseudomonas aeruginosa is the leading cause of morbidity and mortality for adult CF …
Evolutionary Genomics of Niche-Specific Adaptation to the Cystic Fibrosis Lung in Pseudomonas aeruginosa
JR Dettman, R Kassen - Molecular biology and evolution, 2021 - academic.oup.com
The comparative genomics of the transition of the opportunistic pathogen Pseudomonas
aeruginosa from a free-living environmental strain to one that causes chronic infection in the …
aeruginosa from a free-living environmental strain to one that causes chronic infection in the …
Transmission and lineage displacement drive rapid population genomic flux in cystic fibrosis airway infections of a Pseudomonas aeruginosa epidemic strain
D Williams, JL Fothergill, B Evans… - Microbial …, 2018 - microbiologyresearch.org
Pseudomonas aeruginosa chronic infections of cystic fibrosis (CF) airways are a paradigm
for within-host evolution with abundant evidence for rapid evolutionary adaptation and …
for within-host evolution with abundant evidence for rapid evolutionary adaptation and …
Parallel Evolution in Pseudomonas aeruginosa over 39,000 Generations In Vivo
ABSTRACT The Gram-negative bacterium Pseudomonas aeruginosa is a common cause of
chronic airway infections in individuals with the heritable disease cystic fibrosis (CF). After …
chronic airway infections in individuals with the heritable disease cystic fibrosis (CF). After …
Adaptation and genomic erosion in fragmented Pseudomonas aeruginosa populations in the sinuses of people with cystic fibrosis
Pseudomonas aeruginosa notoriously adapts to the airways of people with cystic fibrosis
(CF), yet how infection-site biogeography and associated evolutionary processes vary as …
(CF), yet how infection-site biogeography and associated evolutionary processes vary as …
Pseudomonas aeruginosa evolutionary adaptation and diversification in cystic fibrosis chronic lung infections
Pseudomonas aeruginosa populations undergo a characteristic evolutionary adaptation
during chronic infection of the cystic fibrosis (CF) lung, including reduced production of …
during chronic infection of the cystic fibrosis (CF) lung, including reduced production of …
Evolutionary dynamics of bacteria in a human host environment
Laboratory evolution experiments have led to important findings relating organism
adaptation and genomic evolution. However, continuous monitoring of long-term evolution …
adaptation and genomic evolution. However, continuous monitoring of long-term evolution …
Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection
Abstract The Cystic Fibrosis (CF) lung harbors a complex, polymicrobial ecosystem, in which
Pseudomonas aeruginosa is capable of sustaining chronic infections, which are highly …
Pseudomonas aeruginosa is capable of sustaining chronic infections, which are highly …