Beckwith-Wiedemann syndrome (BWS) is an autosomal dominant disorder of increased
prenatal growth and predisposition to embryonal cancers such as Wilms tumor. BWS is …

Beckwith–Wiedemann syndrome (BWS) is a model human imprinting disorder resulting from
altered activity of one or more genes in the 11p15. 5 imprinted gene cluster. Approximately …

Complex phenotypes and genotypes characterize the human disease, Beckwith–
Wiedemann syndrome (BWS). Genetic and epigenetic mutations are found in five different …

Abstract Background Beckwith-Wiedemann syndrome (BWS) is a congenital overgrowth
disorder associated with abnormalities in 11p15. 5 imprinted genes. The most common …

Beckwith–Wiedemann syndrome (BWS) is an overgrowth syndrome, which, in 50–60% of
sporadic cases, is caused by hypomethylation of KCNQ1OT1 differentially methylated region …

Background: Beckwith-Wiedemann syndrome (BWS) is an overgrowth syndrome with an
increased risk of cancer. Most BWS patients show a molecular defect in the 11p15 region …

The imprinted 11p15 region is organized in two domains, each of them under the control of
its own imprinting control region (ICR1 for the IGF2/H19 domain and ICR2 for the …

Genomic imprinting plays a fundamental role in cancer and some hereditary diseases,
including Beckwith–Wiedemann syndrome (BWS), a disorder of prenatal overgrowth and …

Macroglossia, prenatal or postnatal overgrowth, and abdominal wall defects (omphalocele,
umbilical hernia, or diastasis recti) permit early recognition of Beckwith-Wiedemann …

The imprinted expression of the IGF2 and H19 genes is controlled by the Imprinting Centre 1
(IC1) at chromosome 11p15. 5. This is a methylation-sensitive chromatin insulator that works …