Utilization of physiologically based pharmacokinetic modeling in clinical pharmacology and therapeutics: an overview
C Perry, G Davis, TM Conner, T Zhang - Current Pharmacology Reports, 2020 - Springer
The purpose of this review was to assess the advancement of applications for
physiologically based pharmacokinetic (PBPK) modeling in various therapeutic areas. We …
physiologically based pharmacokinetic (PBPK) modeling in various therapeutic areas. We …
Quantification of the impact of partition coefficient prediction methods on physiologically based pharmacokinetic model output using a standardized tissue composition
K Utsey, MS Gastonguay, S Russell, R Freling… - Drug Metabolism and …, 2020 - ASPET
Tissue: plasma partition coefficients are key parameters in physiologically based
pharmacokinetic (PBPK) models, yet the coefficients are challenging to measure in vivo …
pharmacokinetic (PBPK) models, yet the coefficients are challenging to measure in vivo …
Prediction of drug disposition on the basis of its chemical structure
D Stepensky - Clinical pharmacokinetics, 2013 - Springer
The chemical structure of any drug determines its pharmacokinetics and
pharmacodynamics. Detailed understanding of relationships between the drug chemical …
pharmacodynamics. Detailed understanding of relationships between the drug chemical …
A paradigm shift in Pharmacokinetic–Pharmacodynamic (PKPD) modeling: Rule of thumb for estimating free drug level in tissue compared with plasma to guide drug …
P Poulin - Journal of pharmaceutical sciences, 2015 - Elsevier
ABSTRACT A basic assumption in pharmacokinetics-pharmacodynamics research is that
the free drug concentration is similar in plasma and tissue, and, hence, in vitro plasma data …
the free drug concentration is similar in plasma and tissue, and, hence, in vitro plasma data …
Physiologically Based Pharmacokinetics Joined With In Vitro–In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology
A Rostami‐Hodjegan - Clinical Pharmacology & Therapeutics, 2012 - Wiley Online Library
Classic pharmacokinetics (PK) rarely takes into account the full knowledge of physiology
and biology of the human body. However, physiologically based PK (PBPK) is built mainly …
and biology of the human body. However, physiologically based PK (PBPK) is built mainly …
Physiological‐based pharmacokinetic modeling trends in pharmaceutical drug development over the last 20‐years; in‐depth analysis of applications, organizations …
E El‐Khateeb, S Burkhill, S Murby… - … & Drug Disposition, 2021 - Wiley Online Library
We assess the advancement of physiologically based pharmacokinetic (PBPK) modeling
and simulation (M&S) over the last 20 years (start of 2000 to end of 2019) focusing on the …
and simulation (M&S) over the last 20 years (start of 2000 to end of 2019) focusing on the …
Using expression data for quantification of active processes in physiologically based pharmacokinetic modeling
M Meyer, S Schneckener, B Ludewig, L Kuepfer… - Drug Metabolism and …, 2012 - ASPET
Active processes involved in drug metabolization and distribution mediated by enzymes,
transporters, or binding partners mostly occur simultaneously in various organs. However, a …
transporters, or binding partners mostly occur simultaneously in various organs. However, a …
Physiologically‐based pharmacokinetic models for evaluating membrane transporter mediated drug–drug interactions: current capabilities, case studies, future …
KS Taskar, V Pilla Reddy, H Burt… - Clinical …, 2020 - Wiley Online Library
Physiologically‐based pharmacokinetic (PBPK) modeling has been extensively used to
quantitatively translate in vitro data and evaluate temporal effects from drug–drug …
quantitatively translate in vitro data and evaluate temporal effects from drug–drug …
Basic concepts in physiologically based pharmacokinetic modeling in drug discovery and development
HM Jones, K Rowland‐Yeo - CPT: pharmacometrics & systems …, 2013 - Wiley Online Library
The aim of this tutorial is to introduce the concept of physiologically based pharmacokinetic
(PBPK) modeling to individuals in the pharmaceutical industry who may be relatively new to …
(PBPK) modeling to individuals in the pharmaceutical industry who may be relatively new to …
Predicting transporter mediated drug–drug interactions via static and dynamic physiologically based pharmacokinetic modeling: A comprehensive insight on where …
G Vijaywargi, S Kollipara, T Ahmed… - … & Drug Disposition, 2023 - Wiley Online Library
The greater utilization and acceptance of physiologically‐based pharmacokinetic (PBPK)
modeling to evaluate the potential metabolic drug–drug interactions is evident by the …
modeling to evaluate the potential metabolic drug–drug interactions is evident by the …