Role of PARP-1 in mitochondrial homeostasis
Background Nuclear poly (ADP-ribose) polymerase-1 (PARP-1) is a well characterised
protein that accounts for the majority of PARylation reactions using NAD+ as a substrate …
protein that accounts for the majority of PARylation reactions using NAD+ as a substrate …
Mitochondrial poly (ADP-ribose) polymerase: The Wizard of Oz at work
Among multiple members of the poly (ADP-ribose) polymerase (PARP) family, PARP1
accounts for the majority of PARP activity in mammalian cells. Although PARP1 is …
accounts for the majority of PARP activity in mammalian cells. Although PARP1 is …
Mitochondrial localization of PARP-1 requires interaction with mitofilin and is involved in the maintenance of mitochondrial DNA integrity
MN Rossi, M Carbone, C Mostocotto… - Journal of Biological …, 2009 - ASBMB
Poly (ADP-ribose) polymerase-1 (PARP-1) is a predominantly nuclear enzyme that exerts
numerous functions in cellular physiology and pathology, from maintenance of DNA stability …
numerous functions in cellular physiology and pathology, from maintenance of DNA stability …
Poly (ADP-ribose) polymerase-1 is a nuclear epigenetic regulator of mitochondrial DNA repair and transcription
Poly (ADP-ribose) polymerase-1 (PARP-1) is a NAD-consuming enzyme with an emerging
key role in epigenetic regulation of gene transcription. Although PARP-1 expression is …
key role in epigenetic regulation of gene transcription. Although PARP-1 expression is …
Mitochondrial protection by PARP inhibition
F Gallyas Jr, B Sumegi - International journal of molecular sciences, 2020 - mdpi.com
Inhibitors of the nuclear DNA damage sensor and signalling enzyme poly (ADP-ribose)
polymerase (PARP) have recently been introduced in the therapy of cancers deficient in …
polymerase (PARP) have recently been introduced in the therapy of cancers deficient in …
Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial …
The positive role of PARP1 in regulation of various nuclear DNA transactions is well
established. Although a mitochondrial localization of PARP1 has been suggested, its role in …
established. Although a mitochondrial localization of PARP1 has been suggested, its role in …
[HTML][HTML] The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease
While originally described as DNA damage repair agents, recent data suggest a role for poly
(ADP-ribose) polymerase (PARP) enzymes in metabolic regulation by influencing …
(ADP-ribose) polymerase (PARP) enzymes in metabolic regulation by influencing …
Parkin‐independent mitophagy requires D rp1 and maintains the integrity of mammalian heart and brain
Y Kageyama, M Hoshijima, K Seo, D Bedja… - The EMBO …, 2014 - embopress.org
Mitochondrial dynamics and mitophagy have been linked to cardiovascular and
neurodegenerative diseases. Here, we demonstrate that the mitochondrial division dynamin …
neurodegenerative diseases. Here, we demonstrate that the mitochondrial division dynamin …
Mitochondrial PARP1 regulates NAD+-dependent poly ADP-ribosylation of mitochondrial nucleoids
PARPs play fundamental roles in multiple DNA damage recognition and repair pathways.
Persistent nuclear PARP activation causes cellular NAD+ depletion and exacerbates …
Persistent nuclear PARP activation causes cellular NAD+ depletion and exacerbates …
Mitochondrial and nuclear cross talk in cell death: parthanatos
SA Andrabi, TM Dawson… - Annals of the New York …, 2008 - Wiley Online Library
Poly (ADP‐ribose) polymerase‐1 (PARP‐1) is an abundant nuclear protein best known to
facilitate DNA base excision repair. Recent work has expanded the physiologic functions of …
facilitate DNA base excision repair. Recent work has expanded the physiologic functions of …