Muscular dystrophies are inherited neuromuscular diseases, resulting in progressive
disability and often affecting life expectancy. The most severe, common types are Duchenne …

Highlights•Inflammation is a pathological hallmark of muscular dystrophies.•Dystrophin
and/or sarcoglycans loss alter eATP degradation and P2X7 signalling in muscles.•Treatment …

Dystrophinopathy and sarcoglycanopathies are incurable diseases caused by mutations in
the genes encoding dystrophin or members of the dystrophin associated protein complex …

Duchenne muscular dystrophy (DMD) is a lethal inherited muscle disorder. Pathological
characteristics of DMD skeletal muscles include, among others, abnormal Ca2+ …

Background Duchenne muscular dystrophy (DMD) is the most common inherited muscle
disease, leading to severe disability and death in young men. Death is caused by the …

Duchenne muscular dystrophy (DMD) is the most common inherited muscle disease leading
to severe disability and death of young men. Current interventions are palliative as no …

Skeletal muscle (SM) is a heterogeneous and dynamic tissue that changes significantly in its
form and function in response to external and internal stimuli and throughout life, from …

P2X7 purinoceptor promotes survival or cytotoxicity depending on extracellular adenosine
triphosphate (ATP) stimulus intensity controlling its ion channel or P2X7-dependent large …

ATP is an important extracellular signaling molecule mediating its effects by activation of
P2X and P2Y receptors. P2 receptors are expressed during muscle development, and …

Following molecular and immunohistochemical analysis of the purinergic P2X4 receptor
subunit in dystrophin-deficient muscle we have identified a distinct subpopulation of P2X4 …