[HTML][HTML] Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD)

M Fava, MP Freeman, M Flynn, H Judge… - Molecular …, 2020 - nature.com
Numerous placebo-controlled studies have demonstrated the ability of ketamine, an NMDA
receptor antagonist, to induce rapid (within hours), transient antidepressant effects when …

Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression

M Aan Het Rot, KA Collins, JW Murrough, AM Perez… - Biological …, 2010 - Elsevier
BACKGROUND: A single subanesthetic (intravenous) IV dose of ketamine might have rapid
but transient antidepressant effects in patients with treatment-resistant depression (TRD) …

Pilot dose–response trial of iv ketamine in treatment-resistant depression

R Lai, N Katalinic, P Glue, AA Somogyi… - The World Journal of …, 2014 - Taylor & Francis
Objectives. Research studies have reported impressive antidepressant effects with ketamine
but significant knowledge gaps remain over the best method of administering ketamine, and …

Ketamine safety and tolerability in clinical trials for treatment-resistant depression

LB Wan, CF Levitch, AM Perez, JW Brallier… - The Journal of clinical …, 2014 - psychiatrist.com
Objective: Ketamine has demonstrated rapid antidepressant effects in patients with
treatment-resistant depression (TRD); however, the safety and tolerability of ketamine in this …

Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial

JW Murrough, DV Iosifescu, LC Chang… - American Journal of …, 2013 - Am Psychiatric Assoc
Objective Ketamine, a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist, has
shown rapid antidepressant effects, but small study groups and inadequate control …

A double-blind, randomized, placebo-controlled, dose-frequency study of intravenous ketamine in patients with treatment-resistant depression

JB Singh, M Fedgchin, EJ Daly… - American Journal of …, 2016 - Am Psychiatric Assoc
Objective: Ketamine, an N-methyl-d-aspartate glutamate receptor antagonist, has
demonstrated a rapid-onset antidepressant effect in patients with treatment-resistant …

A systematic review and meta-analysis of the efficacy of intravenous ketamine infusion for treatment resistant depression: January 2009–January 2019

WS Marcantoni, BS Akoumba, M Wassef… - Journal of affective …, 2020 - Elsevier
Background Sub-anaesthetic administration of ketamine is an emerging practice in patients
presenting treatment resistant depression (TRD), however several outstanding questions …

Clinical predictors of ketamine response in treatment-resistant major depression

MJ Niciu, DALDF Ionescu, S Guevara… - The Journal of clinical …, 2014 - psychiatrist.com
Objective: The N-methyl-d-aspartate receptor antagonist ketamine has rapid antidepressant
effects in treatment-resistant major depressive disorder (MDD) and bipolar depression …

Single, repeated, and maintenance ketamine infusions for treatment-resistant depression: a randomized controlled trial

JL Phillips, S Norris, J Talbot… - American Journal of …, 2019 - Am Psychiatric Assoc
Objective: Subanesthetic ketamine doses have been shown to have rapid yet transient
antidepressant effects in patients with treatment-resistant depression, which may be …

Repeated intravenous ketamine therapy in a patient with treatment-resistant major depression

M Liebrenz, R Stohler, A Borgeat - The World Journal of Biological …, 2009 - Taylor & Francis
Background: The intravenous administration of ketamine, an N-methyl-d-aspartate receptor
antagonist, results in a great improvement of depression symptoms, but it is not clear for how …