Introduction Cell-penetrating peptide (CPP) technologies represent an important strategy to
address drug delivery to specific intracellular compartments by covalent conjugation to …

Introduction: One of the major limiting steps in order to have an effective drug is the passage
through one or more cell membranes to reach its site of action. To reach the action-site, the …

Introduction: Delivery of macromolecular drugs is an important field in medical research.
However, macromolecules are usually unable to cross the cell membrane without the …

The presence of cell and tissue barriers together with the low biomembrane permeability of
various therapeutics often hampers systemic drug distribution; thus, most of the available …

Biological cell membranes are a natural barrier for living cells. In the last few decades, the
cell membrane has been the main hurdle in the efficient delivery of bioactive and therapeutic …

Abstracts Cell-penetrating peptides (CPPs), also known as protein transduction domains,
are a class of diverse amino acid sequences with the ability to cross cellular membranes …

Peptides and proteins, two important classes of biomacromolecules, play important roles in
the biopharmaceuticals field. As compared with traditional drugs based on small molecules …

Extensive research has been undertaken in the pursuit of anticancer therapeutics. Many
anticancer drugs require specificity of delivery to cancer cells, whilst sparing healthy tissue …

Cell-penetrating peptides (CPPs) have found numerous applications in biology and
medicine since the first synthetic cell-permeable sequence was identified two decades ago …

Cell-penetrating peptides (CPPs), developed for more than 30 years, are still being
extensively studied due to their excellent delivery performance. Compared with other …