Considered by some to be among the simpler forms of life, viruses represent highly evolved
natural vectors for the transfer of foreign genetic information into cells. This attribute has led …

Gene therapy includes the application of various viral vectors, which represent most types
and families of viruses, suitable for infection of mammalian host cells. Both hereditary …

As Theodore Friedmann notes in “Overcoming the Obstacles to Gene Therapy” on page 96
of this issue, many efforts at developing gene therapy employ modified viruses to shuttle into …

The efficient delivery of therapeutic genes and appropriate gene expression are the crucial
issues for clinically relevant gene therapy. Viruses are naturally evolved vehicles which …

The use of viruses to transduce genes of interest into mammalian cells has been extremely
revolutionary, both in terms of laboratory research and for clinical purposes. This approach …

No matter what their origin, strain and family, viruses have evolved exquisite strategies to
reach and penetrate specific target cells where they hijack the cellular machinery to express …

To achieve therapeutic success, transfer vehicles for gene therapy must be capable of
transducing target cells while avoiding impact on non-target cells. Despite the high …

The concept of gene therapy was envisioned soon after the emergence of restriction
endonucleases and subcloning of mammalian genes in phage and plasmids. Over the …

Problems related to the safety and efficacy of gene therapies have checked the enthusiasm
once surrounding this field, though it remains a promising approach for the treatment of …

Although most research in the field of somatic gene therapy has investigated the use of
recombinant viruses for transferring genes into somatic target cells, various methods for …