Development of multicellular organisms is a highly orchestrated process, with cells
responding to factors and features present in the extracellular milieu. Changes in the …

The maintenance of stem cell pluripotency or stemness is crucial to embryonic development
and differentiation. The mechanical or physical microenvironment of stem cells, which …

Stem cell fate and function are dynamically modulated by the interdependent relationships
between biochemical and biophysical signals constituting the local 3D microenvironment …

The biochemical cues and topographical architecture of the extracellular environment
extensively influence ES cell fate. The microenvironment surrounding the developing …

During embryogenesis, organisms acquire their shape given boundary conditions that
impose geometrical, mechanical and biochemical constraints. A detailed integrative …

Mechanical forces are critical to embryogenesis, specifically, in the lineage-specification
gastrulation phase, whereupon the embryo is transformed from a simple spherical ball of …

The self-organization of embryonic stem cells (ESCs) into organized tissues with three
distinct germ layers is critical to morphogenesis and early development. While the regulation …

Regenerative medicine is predicated on understanding the mechanisms regulating
development and applying these conditions to direct stem cell fate. Embryogenesis is …

Embryonic stem cells (ESC) are both a potential source of cells for tissue replacement
therapies and an accessible tool to model early embryonic development. Chemical factors …

Stem cell fate decisions are driven by a broad array of signals, both chemical and
mechanical. Although much progress has been made in our understanding of the impact of …