Pluripotent embryonic stem cells represent a promising renewable cell source to generate a
variety of differentiated cell types including hepatocyte lineage cells, and may ultimately be …

Obtaining functional hepatocytes from human pluripotent stem cells (hPSCs) holds great
potential for applications in drug safety testing, as well in the field of regenerative medicine …

In many cell types, several cellular processes, such as differentiation of stem/precursor cells,
maintenance of differentiated phenotype, motility, adhesion, growth, and survival, strictly …

A critical shortage of donor livers for treating end-stage liver failure signifies the urgent need
for alternative treatment options. Hepatocyte-like cells (HLC) derived from various stem cells …

Pluripotent stem cell derived liver cells (hepatocytes) represent a promising alternative to
primary tissue for biological and clinical applications. To date, most hepatocyte maintenance …

Primary hepatocytes, as the gold standard cell type for in vitro models, lose their
characteristic morphology and functions after few days. There is an urgent need to develop …

Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) provide
an unlimited source for the generation of human hepatocytes, owing to their indefinite self …

Liver tissue engineering requires a suitable cell source, methodologies to assemble the
cells within their niche microenvironments in a spatially defined manner, and vascularization …

Induced pluripotent stem cells (iPSCs) are new diagnostic and potentially therapeutic tools
to model disease and assess the toxicity of pharmaceutical medications. A common …

Liver tissue engineering is promising as an alternative strategy to treat liver failure. However,
generating functional hepatocytes from stem cells is conventionally restricted by the …