Background Nephron progenitor cells (NPCs) give rise to all segments of functional
nephrons and are of great interest due to their potential as a source for novel treatment …

Recent studies indicate that nephron progenitor cells of the embryonic kidney are arranged
in a series of compartments of an increasing state of differentiation. The earliest progenitor …

GDNF signaling through the Ret receptor tyrosine kinase (RTK) is required for ureteric bud
(UB) branching morphogenesis during kidney development in mice and humans …

Intercellular signaling molecules and their receptors, whose expression must be tightly
regulated in time and space, coordinate organogenesis. Regulators of intracellular signaling …

The kidney is a classic model for studying mechanisms of inductive tissue interactions
associated with the epithelial branching common to many embryonic organs, but the …

Background Studies in mice suggest that perturbations of the GDNF-Ret signaling pathway
are a major genetic cause of congenital anomalies of the kidney and urinary tract (CAKUT) …

Previous studies using transgenic Pax3cre mice have revealed roles for fibroblast growth
factor receptors (Fgfrs) and Fgfr substrate 2α (Frs2α) signaling in early metanephric …

Branching of ureteric bud-derived epithelial tubes is a key morphogenetic process that
shapes development of the kidney. Glial cell line-derived neurotrophic factor (GDNF) …

Abstract DLG1 (discs-large homolog 1) and CASK (calcium/calmodulin-dependent serine
protein kinase) interact at membrane-cytoskeleton interfaces and function as scaffolding …

FGFRL1 is a member of the fibroblast growth factor receptor family. It plays an essential role
during branching morphogenesis of the metanephric kidneys, as mice with a targeted …