Antibody-dependent cellular cytotoxicity (ADCC) is mediated through the engagement of the
Fc segment of antibodies with Fcγ receptors (FcγRs) on immune cells upon binding of tumor …

Antibody-dependent cellular cytotoxicity (ADCC) is a major mechanism by which antibodies
exert anti-tumor effects. Here, we show that Fc multimerization augments the binding …

Fc engineering is a promising approach to enhance the antitumor efficacy of monoclonal
antibodies (mAbs) through antibody-dependent cell-mediated cytotoxicity (ADCC). Glyco …

Enhancing the effector function by optimizing the interaction between Fc and Fcγ receptor
(FcγR) is a promising approach to enhance the potency of anticancer monoclonal antibodies …

The contribution of Fc-mediated effector functions to the therapeutic efficacy of some
monoclonal antibodies has motivated efforts to enhance interactions with Fcγ receptors …

Despite the exquisite specificity and high affinity of antibody-based cancer therapies,
treatment side effects can occur since the tumor-associated antigens targeted are also …

Engineering the antibody Fc region to enhance the cytotoxic activity of therapeutic
antibodies is currently an active area of investigation. The contribution of complement to the …

Binding of antibodies to their receptors is a core component of the innate immune system.
Understanding the precise interactions between antibodies and their Fc receptors has led to …

Antibody-dependent cell-mediated cytotoxicity, a key effector function for the clinical efficacy
of monoclonal antibodies, is mediated primarily through a set of closely related Fcγ …

Antibody-based therapeutics has emerged as a major tool in cancer treatment. Guided by
the superb specificity of the antibody variable domain, it allows the precise targeting of …