Melatonin exerts a wide range of effects among various tissues and organs. However, there
is currently no study to investigate the genetic determinants of melatonin secretion. Here, we …

Melatonin is predominantly involved in signaling circadian and seasonal rhythms, and its
synthesis is regulated by the environmental light/dark cycle. The selection pressure by …

Purpose Heart disease is a major cause of mortality and disability worldwide. Melatonin is a
neuroendocrine hormone and has been found to be protective in heart disease. However …

Background Genome-wide association studies (GWAS) in White Europeans have shown
that genetic variation rs10830963 in melatonin receptor 1B gene (MTNR1B) is associated …

Understanding the complete map of melatonin synthesis, the information transfer network
among circadian genes in pineal gland, promises to resolve outstanding issues in endocrine …

This study investigated whether and how fetal malnutrition would influence endogenous
melatonin synthesis, and whether such effect of fetal malnutrition would transmit to the next …

A recent study has investigated the relationship between the circadian neurohormone
melatonin and glucose homeostasis and its implications for type 2 diabetes (T2D) risk …

Several psychosocial, sleep/circadian, and cardiometabolic disorders have intricately
interconnected pathologies involving melatonin disruption. Therefore, we hypothesize that …

Background Melatonin is a hormone that is secreted at night by the pineal gland. It exerts its
function by binding to the MT1 and MT2 receptors, which are encoded by the MTNR1A and …

Melatonin counteracts tumor occurrence and tumor cell progression in several cancer types
in vitro and in vivo. It acts predominantly through its melatonin receptor type 1A (MTNR1A) …