Persistent alterations in microglial enhancers in a model of chronic pain
Chronic pain is a common and devastating condition that induces well-characterized
changes in neurons and microglia. One major unanswered question is why these changes …
changes in neurons and microglia. One major unanswered question is why these changes …
[HTML][HTML] Repopulated spinal cord microglia exhibit a unique transcriptome and contribute to pain resolution
Microglia are implicated as primarily detrimental in pain models; however, they exist across
a continuum of states that contribute to homeostasis or pathology depending on timing and …
a continuum of states that contribute to homeostasis or pathology depending on timing and …
Single-cell RNA sequencing reveals time-and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain
Activation of microglia in the spinal cord following peripheral nerve injury is critical for the
development of long-lasting pain hypersensitivity. However, it remains unclear whether …
development of long-lasting pain hypersensitivity. However, it remains unclear whether …
Microglial heterogeneity in chronic pain
G Sideris-Lampretsas, M Malcangio - Brain, Behavior, and Immunity, 2021 - Elsevier
In this review, we report existing preclinical evidence on how the CNS compartment as well
as sex affect microglia functions in health. We highlight that recent advances in …
as sex affect microglia functions in health. We highlight that recent advances in …
Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain
Chronic pain is a debilitating and poorly treated condition whose underlying mechanisms
are poorly understood. Nerve injury and inflammation cause alterations in gene expression …
are poorly understood. Nerve injury and inflammation cause alterations in gene expression …
Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression
G Descalzi, V Mitsi, I Purushothaman, S Gaspari… - Science …, 2017 - science.org
Neuropathic pain is a complex chronic condition characterized by various sensory,
cognitive, and affective symptoms. A large percentage of patients with neuropathic pain are …
cognitive, and affective symptoms. A large percentage of patients with neuropathic pain are …
High-resolution transcriptome analysis reveals neuropathic pain gene-expression signatures in spinal microglia after nerve injury
Microglial cells, the resident immune cells of the spinal cord, become activated in response
to peripheral nerve injury. Microglia activation contributes to the development of neuropathic …
to peripheral nerve injury. Microglia activation contributes to the development of neuropathic …
A comparison of RNA-seq and exon arrays for whole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the rat
Background: The past decade has seen an abundance of transcriptional profiling studies of
preclinical models of persistent pain, predominantly employing microarray technology. In …
preclinical models of persistent pain, predominantly employing microarray technology. In …
Epigenetic mechanisms of chronic pain
Neuropathic and inflammatory pain promote a large number of persisting adaptations at the
cellular and molecular level, allowing even transient tissue or nerve damage to elicit …
cellular and molecular level, allowing even transient tissue or nerve damage to elicit …
Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases
H Wang, H Sun, K Della Penna, RJ Benz, J Xu… - Neuroscience, 2002 - Elsevier
Neuropathic pain is induced by injury or disease of the nervous system. Studies aimed at
understanding the molecular pathophysiology of neuropathic pain have so far focused on a …
understanding the molecular pathophysiology of neuropathic pain have so far focused on a …