Background and purpose: The human multidrug resistance gene (MDR1) encodes for P-
glycoprotein (P-gp) which is a transmembrane transporter protein acts as an efflux pump for …

Drug transporters are increasingly recognized to be important to drug disposition and
response. P‐glycoprotein, the encoded product of the human MDR1 (ABCB1) gene, is of …

This study aimed to assess cytochrome (CY) P450‐2D6* 4 polymorphism relationship with
semen variables in infertile men. In all, 308 men were included; fertile normozoospermia …

BACKGROUND: We investigated the relationship between idiopathic recurrent pregnancy
loss (RPL) and genetic polymorphisms in phase I and phase II detoxification genes which …

The aim of this study was to examine whether an association exists between glutathione S‐
transferase Mu‐1 (GSTM1) gene polymorphism and idiopathic male infertility. Forty‐two men …

Background: X-ray Repair Cross Complementing group 1 (XRCC1) acts as a scaffolding
protein in the converging base excision repair (BER) and single strand break repair (SSBR) …

Several studies have investigated the association between multidrug resistance gene
(MDR1) C1236T polymorphism and leukemia risk, however, these published studies have …

Introduction The multidrug resistance 1 (MDR1) gene plays an important function in
carcinogens detoxification and drugs metabolism. Many authors reported that MDR1 gene …

Abstract Multidrug resistance 1 (MDR1) gene encodes P-glycoprotein (P-gp), which acts as
an efflux pump and provides cell protection against various substances, and its single …

Background Oxidative stress has an undeniable role in the impairment of sperm function
and idiopathic male infertility. On the other hand, the local antioxidant system particularly …