Abstract The Glutathione S-transferases (GSTs) polymorphisms have been implicated in
susceptibility to male idiopathic infertility, but study results are still controversial. To …

Background Genes of different pathways regulate spermatogenesis, and the complexity of
the spermatogenic process indicates that polymorphisms or mutations in these genes could …

Polycystic ovary syndrome is a multifactorial condition associated with reproductive and
endocrine organs and might cause infertility and metabolic abnormalities in childbearing …

Many genetic polymorphisms have been studied extensively to elucidate their role in the
pathophysiology of male infertility. This article presents a review of the literature following a …

The objective of this study was to develop a real-time polymerase chain reaction (PCR)
method to detect MDR1 (human multidrug resistance gene) single nucleotide …

Background: One of the limitations in the treatment of common diseases such as cancer
chemotherapy is development of multidrug resistance (MDR). Polymorphisms could alter the …

Single nucleotide polymorphisms (SNPs) in the MDR1 gene that are responsible for drug
efflux can cause toxicity. Therefore, this study determined the SNPs of the Korean MDR1 …

Objective To assess the correlation of the multidrug resistance-1 (MDR1) gene single
nucleotide polymorphisms (SNP) C1236T, G2677T/A and C3435T with the outcome of …

The multidrug resistance gene (MDR1) plays an important role in the transport of a wide
range of drugs and elimination of xenobiotics from the body. Identification of polymorphisms …

The human MDR1 gene encodes for a P-glycoprotein (PGP), which acts as an efflux pump
that transports a large variety of substrates from the inside of cells to the outside until …