In 1976, Boyar et al made the seminal observation that during the early stages of puberty,
there is a sleep-specific augmentation of pulsatile luteinizing hormone secretion. Building on …

To assess sleep-associated changes in gonadotropin-releasing hormone secretion during
sexual maturation, we studied nighttime and daytime patterns of LH and FSH secretion in …

Neuroendocrine mechanisms underlying the progression of sleep–wake gonadotrophin‐
releasing hormone (GnRH) pulse secretion across puberty have remained enigmatic. Here …

Almost all functions of humans are subject to cyclic changes and are governed by the
nervous system. Most rhythms are driven by an internal biological clock located in the …

Comparable to the period of pubertal transition, sleep also exerts profound effects on
episodic gonadotropin secretion in adult women. During the early follicular phase of the …

Context: During the pubertal transition, LH secretion initially increases only during sleep;
however, its relationship to sleep stage is unknown. Objectives: Our objective was to …

Gonadotropin secretion is pulsatile in prepubertal and early pubertal boys, and the onset of
puberty is characterized by a sleep-associated rise in LH pulse amplitude. To determine …

Exogenous melatonin can be used to treat sleep disturbance in adults, children, and
adolescents. While its short-term use is considered safe, there are some concerns that long …

Context: Early pubertal luteinizing hormone (LH), and by inference gonadotropin-releasing
hormone (GnRH), pulse secretion is marked by high nocturnal but low daytime frequency; …

The fact that the secretion of growth hormone (GH) is markedly stimulated during sleep has
been recognized for more than three decades. Early studies using the first available …