DNA helicases have emerged as a prominent class of nucleic acid-metabolizing enzymes
that play important roles in genome maintenance and cellular homeostasis. DNA helicases …

First discovered in the 1970s, DNA helicases were initially described as enzymes that use
chemical energy to separate (ie, to unwind) the complementary strands of DNA. Because …

Genome integrity is achieved and maintained by the sum of all of the processes in the cell
that ensure the faithful duplication and repair of DNA, as well as its genetic transmission …

Since the discovery of the DNA double helix, there has been a fascination in understanding
the molecular mechanisms and cellular processes that account for:(i) the transmission of …

DNA helicases, known for their fundamentally important roles in genomic stability, are high
profile players in cancer. Not only are there monogenic helicase disorders with a strong …

In this special Methods collection on DNA helicases, I have solicited articles from leading
experts in the field with a priority to gather a defined series of papers on highly relevant …

Helicases have major roles in genome maintenance by unwinding structured nucleic acids.
Their prominence is marked by various cancers and genetic disorders that are linked to …

The unwinding of duplex DNA is a prerequisite for DNA relication and repair, providing the
Single-Stranded DNA (ssDNA) template for DNA polymerase to copy. Duplex DNA must …

ABSTRACT DNA helicases are required for virtually every aspect of DNA metabolism,
including replication, repair, recombination and transcription. A comprehensive description …

DNA helicases are molecular motors that catalyse the unwinding of energetically unstable
structures into single strands and have therefore an essential role in nearly all metabolism …