Asthma is a complex disease with sex-specific differences in prevalence. Candidate gene
studies have suggested that genotype-by-sex interaction effects on asthma risk exist, but this …

Asthma comprised of highly heterogeneous subphenotypes resulting from complex interplay
between genetic and environmental stimuli. While much focus has been placed on extrinsic …

Asthma is a complex disease with striking disparities across racial and ethnic groups.
Despite its relatively high burden, representation of individuals of African ancestry in asthma …

Asthma is a complex disease that varies widely in prevalence across populations. The
extent to which genetic variation contributes to these disparities is unclear, as the genetics …

Asthma is a common disease with a complex risk architecture including both genetic and
environmental factors. We performed a meta-analysis of North American genome-wide …

Background Susceptibility to asthma is influenced by genes and environment; implicated
genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful …

Background Asthma is a chronic respiratory disease whose genetic basis has been
explored for over two decades, most recently via genome-wide association studies. We …

Rationale Asthma has substantial morbidity and mortality and a strong genetic component,
but identification of genetic risk factors is limited by availability of suitable studies. Objectives …

In the era of genome-wide association (GWA) studies, delineating pathogenic asthma
genetic pathways has provided both challenges and opportunities. Initial GWA studies on …

Asthma is a heterogeneous respiratory disease reflecting distinct pathobiologic
mechanisms. These mechanisms are based, at least partly, on different genetic factors …