Microglial dysregulation, pertaining to impairment in phagocytosis, clearance and
containment of amyloid-β (Aβ), and activation of neuroinflammation, has been posited to …

Emerging evidence have posited that dysregulated microglia impair clearance and
containment of amyloid‐β (Aβ) species in the brain, resulting in aberrant buildup of Aβ and …

Microglia, the CNS-resident immune cells, play important roles in disease, but the spectrum
of their possible activation states is not well understood. We derived co-regulated gene …

Microgliosis and neuroinflammation are prominent features of Alzheimer's disease (AD).
Disease-responsive microglia meet their increased energy demand by reprogramming …

Microglia are brain-resident myeloid cells and play a major role in the innate immune
responses of the CNS and the pathogenesis of Alzheimer's disease (AD). However, the …

Mononuclear phagocytes are important modulators of Alzheimer9s disease (AD), but the
specific functions of resident microglia, bone marrow-derived mononuclear cells, and …

Microglia are the resident phagocytes of the brain, where they primarily function in the
clearance of dead cells and the removal of un‐or misfolded proteins. The impaired activity of …

Alzheimer's disease (AD) is the most prevalent cause of dementia in humans. This disease
is characterized by the presence of amyloid beta (Ab) deposits in the parenchyma (also …

In Alzheimer's disease (AD), and other conditions affecting integrity of the blood–brain
barrier, microglia can originate in the bone marrow, migrate into the blood and enter the …

Microglia are resident immune cells in the central nervous system (CNS) that originate from
myeloid progenitor cells in the embryonic yolk sac and are maintained independently of …