Chronic systemic sterile inflammation is implicated in the pathogenesis of cerebrovascular
disease and white matter injury. Non-invasive blood markers for risk stratification and …

Objective This investigation aimed at examining whether circulating inflammatory
biomarkers C-reactive protein (CRP), interleukin-6 (IL6), and alpha 1-antichymotrypsin …

Abstract Background Interleukin-23 (IL-23) is required for T helper 17 (Th17) cell responses
and IL-17 production in ischemic stroke. We previously showed that the IL-23/IL-17 axis …

Background and Purpose—It is currently unclear whether midlife systemic inflammation
promotes the development of white matter (WM) abnormalities and small vessel disease in …

Background The objective of this study was to determine whether:(a) markers of acute
inflammation (white cell count, glucose, interleukin-6, C-reactive protein, and fibrinogen) are …

Background Acute brain ischaemia elicits pronounced inflammation, which aggravates
neural injury. However, the mechanisms governing the resolution of acute …

The devastating effect of ischemic stroke is attenuated in mice lacking conventional and
unconventional T cells, suggesting that inflammation enhances tissue damage in cerebral …

The key circulating pro-inflammatory cytokines and their interaction in peripheral
inflammation after acute cerebral ischemia are poorly understood. CD40L, IFN-γ, IL-1α, IL …

Abstract Although interleukin-18 (IL-18) has been implicated in the pathophysiology of
stroke, research findings concerning IL-18 level in stroke have been inconsistent. Thus, we …

As a prototypical proinflammatory cytokine, interleukin-1 (IL-1) exacerbates the early post-
stroke inflammation, whereas its neutralization is protective. To further investigate the …