Background and Purpose—To clarify the role of inflammation in the pathogenesis of small
vessel disease of the brain, we investigated the association between common variation in …

White matter lesions (WML) are common in the ageing brain, often arising in a field effect of
diffuse white matter abnormality. Although WML are associated with cerebral small vessel …

Alzheimer's disease (AD) is one of the most prevalent forms of neurodegenerative disorders.
Previously, we have shown that in vivo administration of an IL-17 neutralizing antibody (IL …

Inflammasomes are known to contribute to brain damage after acute ischemic stroke (AIS).
TAK1 is predominantly expressed in microglial cells and can regulate the NLRP3 …

Acute cerebrovascular disease can affect people at all stages of life, from neonates to the
elderly, with devastating consequences. It is responsible for up to 10% of deaths worldwide …

Objective Intracerebral hemorrhage carries a high mortality and survivors are frequently left
with significant disability. Immunological mechanisms may play an important role in …

INTRODUCTION: Several studies have highlighted the role of interleukin-6 (IL-6) as an early
signal of the inflammatory response following acute ischemic stroke. This study examines …

Stroke represents one of the most important causes of disability and death in developed
countries. However, there is a lack of prognostic tools in clinical practice to monitor the …

Abstract VISSER, K., M. Koggel, J. Blaauw, HJvd Horn, B. Jacobs, and Jvd Naalt. Blood
based biomarkers of inflammation in mild traumatic brain injury: A systematic review …

Background Microglia/macrophages are activated after cerebral ischemic stroke and can
contribute to either brain injury or recovery by polarizing microglia/macrophage into …