Despite remaining questions in this field, such as the specificity of currently available
ROCKi, or the roles of individual ROCK isoforms, recent evidence in experimental diabetes …

Small GTP ases of the R ho family and their down‐stream effectors R ho associated kinases
(ROCKs) are the molecules that converge a spectrum of pathophysiological signals …

Rho-associated kinases (ROCK) are activated in the kidney as well as in cultured cells of
diabetic models and have been implicated in renal pathophysiology. To explore whether …

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease and is
strongly associated with cardiovascular mortality. Given the pandemic of obesity and …

The small GTPase RhoA and its downstream effector, Rho kinase (ROCK), appear to
mediate numerous pathophysiological signals, including smooth muscle cell contraction …

BACKGROUND AND PURPOSE The RhoA/Rho associated kinases (ROCK) pathway has
been implicated in the pathophysiology of diabetic nephropathy (DN). Early stages of …

Rho family GTPases have received increasing atten-tion as critical regulators of cell function
(1). Initially, they were shown to regulate actin dynamics, thereby modulating development …

Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase
that was originally identified as RhoA interacting protein. A diverse array of cellular …

Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase
with essential roles in cytoskeletal functions. Substantial evidence implicates ROCK as a …

Abstract The small GTPase Rho and its effector Rho-kinase (ROCK) are activated in the
diabetic kidney, and recent studies decade have demonstrated that ROCK signaling is an …