RhoA/Rho kinase: a novel therapeutic target in diabetic comp... : Chinese Medical Journal
RhoA/Rho kinase: a novel therapeutic target in diabetic complications : Chinese Medical Journal …

Diabetic kidney disease (DKD) is the leading cause of kidney failure. RhoA/Rho-associated
protein kinase (ROCK) signaling is a recognized mediator of its pathogenesis, largely …

Abstract The small GTPase Rho and its effector Rho kinase (ROCK) are involved in the
pathogenesis of diabetic kidney disease. Rho kinase has two isoforms: ROCK1 and ROCK2 …

The worldwide epidemic scale of diabetes mellitus has been underestimated for a long time.
Currently every 10 seconds one patient dies of diabetes-related pathologies. Given the high …

Rho kinase (ROCK) belongs to a family of Ser/Thr protein kinases that are activated via
interaction with the small GTP-binding protein RhoA. Growing evidence suggests that RhoA …

Dysregulation of fatty acid utilization is increasingly recognized as a significant component
of diabetic kidney disease. Rho-associated, coiled-coil–containing protein kinase (ROCK) is …

OBJECTIVE—RhoA, a small GTPase protein, and its immediate downstream target, Rho
kinase (ROCK), control a wide variety of signal transduction pathways. Recent studies have …

Rho-associated, coiled-coil containing kinases (ROCK) were originally identified as effectors
of the RhoA small GTPase and found to belong to the AGC family of serine/threonine …

Background Accumulating evidence indicates that Rho-associated kinase (ROCK) has been
involved in the pathogenesis of insulin resistance and diabetes. However, little clinical …

Objectives: The RhoA-Rho kinase (ROCK) pathway contributes to a number of diabetic
complications including cardiomyopathy and nephropathy. In this study, we investigated …