Background: Although blockade of Rho kinase with pharmacologic inhibitors ameliorates
renal fibrosis and diabetic kidney disease (DKD), the underlined mechanisms remain largely …

Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD), however,
specific treatment for DN has not yet been elucidated. Therefore, it is critically important to …

Aims We determined the role of the Rho kinase (ROCK) isoforms in diabetes-induced
vascular endothelial dysfunction and enhancement of arginase activity and expression …

RhoA and Rho-kinase (ROCK) participate in a wide variety of cell signal functions such as
cell growth, smooth and cardiac muscle contraction, cytoskeleton rearrangement, cell …

Rho kinase (ROCK) belongs to the AGC (PKA/PKG/PKC) family of serine/threonine kinases
and is a major downstream effector of the small GTPase RhoA. ROCK plays central roles in …

The Rho/rho-kinase (ROCK) pathway has an important role in the pathogenesis of several
cardiovascular diseases. The activation of ROCK is involved in the regulation of vascular …

Insulin signaling is essential for normal glucose homeostasis. Rho-kinase (ROCK) isoforms
have been shown to participate in insulin signaling and glucose metabolism in cultured cell …

RhoB is an early-response gene whose expression is elevated by multiple cellular stresses;
this gene plays an important role in cancer, macrophage motility, and apoptosis. These …

Obesity has increased at an alarming rate in recent years and is now a worldwide public
health problem. Elucidating the mechanisms behind the metabolic dysfunctions associated …

Non-specific inhibition of Rho-associated kinases (ROCKs) alleviated renal fibrosis in the
unilateral ureteral obstruction (UUO) model, while genetic deletion of ROCK1 did not affect …