Objectives The RhoA/ROCK pathway contributes to diabetic cardiomyopathy in part by
promoting the sustained activation of PKCβ2 but the details of their interaction are unclear …

Highlights•Rho-kinase-2 is an important therapeutic target.•ROCK-2 plays a pivotal role in
the pathogenesis of vascular, neuronal disorders and cancer.•ROCK-2 selective targeting …

Control of glomerular blood flow is complex, crucial in renal pathophysiology, and an
attractive target for therapeutic intervention. In this issue of JASN, Cavarape et al.(1) observe …

Endothelial dysfunction in kidney vasculature is the initial and key element for nephropathy
in diabetes mellitus. Accumulating evidence suggests the protective role of Rho kinase …

BACKGROUND 0002 Rho-Kinase (ROCK) is a member of the serine threonine protein
kinase family. ROCK exists in two iso forms, ROCK1, and ROCK2 (T. Ishizaki et al., EMBO J …

Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …

Background—Elevated levels of plasminogen activator inhibitor-1 (PAI-1) are associated
with myocardial infarction and stroke, especially in patients with diabetes. The induction of …

Glomerular matrix accumulation is a hallmark of diabetic nephropathy. We previously
showed that RhoA activation by high glucose in mesangial cells (MC) leads to matrix …

Rho-kinase (ROCKs) belongs to the family of serine/threonine kinases and is an important
downstream effector of the small GTP-binding protein RhoA. There are two isoforms of Rho …

Rho-kinase 1 (ROCK1) has been implicated in diverse metabolic functions throughout the
body, with promising evidence identifying ROCK1 as a therapeutic target in diabetes and …