Twenty years ago, Rho-kinase was identified as an important downstream effector of the
small GTP-binding protein, RhoA. Thereafter, a series of studies demonstrated the important …

The goals of our study were to evaluate the haplotype pattern at the Rho-associated kinase
2 (ROCK2) locus and prospectively test the association between the ROCK2 haplotype …

Both RhoA/ROCK and NF-κB signaling pathways play important roles in the pathogenesis of
diabetic nephropathy (DN). However, it remains unknown whether and how RhoA/ROCK …

Atherosclerosis is a chronic inflammatory disease of the arteries characterized by the
accumulation of inflammatory cells in the arterial wall. Hypertension, dyslipidemia, and …

RhoA/Rho kinase (ROCK) signaling has been suggested to be involved in diabetic
nephropathy (DN) pathogenesis. Altered expression of connexin43 (Cx43) has been found …

Arterial hypertension is a common health problem that affects 25% of the adult population in
industrialized societies, and is a major risk factor for myocardial infarction and stroke …

RhoA/Rho-kinase pathway plays an important role in many pathological conditions. RhoA
participates in the regulation of smooth muscle tone and activates many downstream …

It has been shown that blockade of Rho kinase with pharmacologic inhibitors inhibits renal
fibrosis. This study examined the role of Rho kinase in renal fibrosis in the unilateral ureteral …

Background The small guanosine triphosphatase RhoA and its direct target Rho kinase
(ROCK) play important roles in cardiovascular pathophysiology. Activated ROCK …

Rho-associated kinases (ROCKs), the immediate downstream targets of RhoA, are
ubiquitously expressed serine-threonine protein kinases that are involved in diverse cellular …