Rho kinase (ROCK) has been implicated in physiological and pathophysiological
processes, including regulation of vascular function. ROCK signaling is thought to be a …

Background Smooth muscle contraction is regulated by the small GTPase RhoA and its
target, Rho-kinase and recent evidence indicates that nitric oxide (NO) causes vasodilation …

Over the last decade, numerous advances have been made in characterizing the various
roles of rho kinase in vascular function. In light of extensive evidence for the involvement of …

The small GTPase Rho and its downstream effector Rho-kinase contribute to agonist-
induced vascular contraction via Ca 2+ sensitization. Reasonably selective pharmacological …

Rho-associated coiled-coil containing protein kinase 1 (ROCK1) is a key downstream
effector of the small GTPase RhoA. Targeting ROCK1 has shown promising clinical potential …

To determine whether serine/threonine ROCK1 is activated by insulin in vivo in humans and
whether impaired activation of ROCK1 could play a role in the pathogenesis of insulin …

A Rho-associated coiled-coil kinase (ROCK) is identified as a critical downstream effector of
GTPase RhoA which contains two isoforms, ROCK1 (also known as p160ROCK and ROKβ) …

Nox (NADPH oxidase)-derived ROS (reactive oxygen species) have been implicated in the
development of diabetic nephropathy. Of the Nox isoforms in the kidney, Nox4 is important …

Endothelial dysfunction is a key event in the development of vascular disease, and it
precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase …

Atherosclerosis is a complex inflammatory process characterized by the cross-talk between
excessive inflammation and lipid accumulation. In the past few years, compelling evidence …